Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M

doi:10.1038/nature18303

Nature, 534(7607), 383-386, 2016

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M

DOI10.1038/nature18303 PMID27281217

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Abstract

Of the 237 women, 92 (38.8%) had experienced both a normal and a toxaemic pregnancy, and 72 (78%) contrasted the sense of well-being associated with a normal pregnancy with the malaise and minor symptoms characteristic of the toxaemic condition. The striking feature of these early minor symptoms of toxaemia was their close resemblance to those of premenstrual syndrome noted in an earlier investigation (Greene and Dalton, 1953), most patients confirming that the minor symptoms during their toxaemic pregnancy were similar, though of increased severity, to those experienced in the premenstruum, irrespective of whether the onset of premenstrual syndrome had preceded or followed the toxaemic pregnancy.

Topics

Ethics/Philosophy Infertility

pronuclear transfer mitochondrial disease prevention, mitochondrial DNA replacement therapy, mitochondrial donation clinical application, three-parent IVF mitochondrial disease, nuclear genome transfer oocytes, mtDNA disease prevention technique, mitochondrial replacement therapy ethics, pronuclear transfer zygote manipulation, inherited mitochondrial disorder prevention, assisted reproduction mitochondrial disease

PMID 27281217 27281217 DOI 10.1038/nature18303 10.1038/nature18303

Cite this article

Hyslop, L. A., Blakeley, P., Craven, L., Richardson, J., Fogarty, N. M. E., Fragouli, E., Lamb, M., Wamaitha, S. E., Prathalingam, N., Zhang, Q., O'Keefe, H., Takeda, Y., Arizzi, L., Alfarawati, S., Tuppen, H. A., Irving, L., Kalleas, D., Choudhary, M., Wells, D., . . . Herbert, M. (2016). Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. *Nature*, *534*(7607), 383-386. https://doi.org/10.1038/nature18303

Keywords

Adult, Blastocyst/cytology/metabolism, Cell Nucleus/genetics/metabolism, Cytoplasm/genetics/metabolism, DNA, Mitochondrial/analysis/genetics, Female, Gene Expression Profiling, Humans, Male, Meiosis, Mitochondria/genetics/metabolism, Mitochondrial Diseases/genetics/pathology/prevention & Control, Mitochondrial Replacement Therapy/methods, Nuclear Transfer Techniques, Stem Cells/cytology/metabolism, Translational Research, Biomedical, Young Adult, Zygote/cytology/metabolism, DNA, Mitochondrial

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Abstract

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