Gynecologic and Obstetric Investigation, 26(2), 89-103
Attempts to induce ovulation have been made since the early 1920s, but the major breakthrough came in the early 1960s with the introduction of clomiphene citrate and the gonadotropins. Additional progress was made in the early 1970s with the introduction of bromocriptine and in the early 1980s with the introduction of pulsatile GnRH. At the present, 'pure' FSH and GnRH agonists are being evaluated as adjuncts to HMG for induction of ovulation. As more insight is gained in the neuroendocrine control of the ovulating cycle, we may soon be able to induce ovulation by direct manipulation of the central nervous system.
Jewelewicz, R., & Gindoff, P. R. (1988). Induction of ovulation--past, present and future. *Gynecologic and obstetric investigation*, *26*(2), 89-103. https://doi.org/10.1159/000293679
Jewelewicz R, Gindoff PR. Induction of ovulation--past, present and future. Gynecol Obstet Invest. 1988;26(2):89-103. doi:10.1159/000293679
Jewelewicz, Raphael, and Paul R. Gindoff. "Induction of ovulation--past, present and future." *Gynecologic and obstetric investigation*, vol. 26, no. 2, 1988, pp. 89-103.
Chorionic Gonadotropin/administration & Dosage, Clomiphene/administration & Dosage, Female, Glucocorticoids/administration & Dosage, Humans, Menotropins/administration & Dosage, Ovary/surgery, Ovulation Induction/methods, Pituitary Hormone-Releasing Hormones/administration & Dosage, Pregnancy, Pregnancy Outcome, Pregnancy, Multiple, Chorionic Gonadotropin, Glucocorticoids, Pituitary Hormone-Releasing Hormones, Clomiphene, Menotropins