Obata, K., & Hoshiai, H. (2000). Common genetic changes between endometriosis and ovarian cancer. Gynecologic and Obstetric Investigation, 50(Suppl. 1), 39-43. https://doi.org/10.1159/000052877
Obata K, Hoshiai H. Common genetic changes between endometriosis and ovarian cancer. Gynecol Obstet Invest. 2000;50(Suppl. 1):39-43. doi:10.1159/000052877
Obata, Koshiro, and Hiroshi Hoshiai. "Common genetic changes between endometriosis and ovarian cancer." Gynecologic and Obstetric Investigation, vol. 50, no. Suppl. 1, 2000, pp. 39-43.
We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions.
