Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy

Hameed C, Tejani N, Verma UL, Archbald F

doi:10.1016/0002-9378(84)90111-x

American Journal of Obstetrics and Gynecology, 149(7), 726-730, 1984

Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy

C Hameed , Uma Verma , F Archbald

Author affiliations

Nassau University Medical Center ROR

DOI10.1016/0002-9378(84)90111-x PMID6465222

Read at publisher

Abstract

Thirty-seven consecutive patients with singleton pregnancies in "uncomplicated" preterm labor with intact membranes suitable for tocolysis were evaluated for evidence of silent chorioamnionitis by means of maternal serum C-reactive protein and amniotic fluid white blood cell count, Gram stain, and cultures. Abnormalities in these markers of infection were found to be significantly more common in cases that were refractory to tocolysis. These cases also showed both pathologic evidence of chorioamnionitis and a significantly greater neonatal early infectious morbidity. We conclude that silent chorioamnionitis is a significant cause of "uncomplicated" preterm labor refractory to conventional methods of tocolysis.

Topics

Pregnancy > Preterm Birth > Subclinical Chorioamnionitis Pregnancy > Preterm Labor > Tocolysis Failure Diagnostics > Infectious Markers > Amniotic Fluid Analysis

silent chorioamnionitis preterm labor tocolytic failure, subclinical intrauterine infection refractory preterm labor, C-reactive protein amniotic fluid infection preterm labor, chorioamnionitis tocolysis resistant preterm labor intact membranes, amniotic fluid culture Gram stain white blood cell preterm, silent infection preterm labor diagnosis management, Hameed Tejani silent chorioamnionitis tocolytic therapy, subclinical chorioamnionitis neonatal infectious morbidity, preterm labor etiology infection biomarkers CRP, tocolytic therapy failure intrauterine infection diagnosis

PMID 6465222 6465222 DOI 10.1016/0002-9378(84)90111-x 10.1016/0002-9378(84)90111-x

Cite this article

Hameed, C., Tejani, N., Verma, U. L., & Archbald, F. (1984). Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy. *American journal of obstetrics and gynecology*, *149*(7), 726-730. https://doi.org/10.1016/0002-9378(84)90111-x

Keywords

Amnion/pathology, Amniotic Fluid/analysis/cytology/microbiology, C-Reactive Protein/analysis, Chorion/pathology, Drug Resistance, Female, Humans, Inflammation/complications/diagnosis, Leukocyte Count, Magnesium Sulfate/therapeutic Use, Obstetric Labor, Premature/etiology/prevention & Control, Placenta Diseases/complications/diagnosis, Pregnancy, Pregnancy Complications, Infectious/diagnosis/physiopathology, Prospective Studies, Ritodrine/therapeutic Use, Magnesium Sulfate, C-Reactive Protein, Ritodrine

Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy

Abstract

Topics

Cite this article

Keywords

Related articles

Incident endometriosis diagnosis and anti-müllerian hormone (AMH): how surgical staging and typology relate to serum AMH levels

"Uterine closure after cesarean delivery: surgical technique, biological rationale, and clinical implications."

Reduced risk of cesarean delivery with oxytocin discontinuation in active labor: a systematic review and meta-analysis

Prevalence and risk factors for postpartum depression 2 months after a vaginal delivery: a prospective multicenter study