Endometrial Hyperplasia
A pathologic overgrowth of the endometrium characterized by increased number and crowding of endometrial glands, usually caused by prolonged estrogen exposure without sufficient progesterone (unopposed estrogen). This condition is not cancer, but some forms are precancerous and can progress to endometrial adenocarcinoma if untreated. Classified as "without atypia" (lower risk) or "atypical" (endometrial intraepithelial neoplasia, higher cancer risk). Often presents with abnormal uterine bleeding: heavy, frequent, irregular, or postmenopausal.
RRM relevance: Endometrial hyperplasia is driven by hormonal imbalance, especially chronic or intermittent anovulation and other causes of unopposed estrogen: PCOS, obesity, estrogen-only therapy, and estrogen-secreting tumors. In RRM practice, cycle charting identifies anovulatory patterns early, and targeted progesterone therapy addresses the hormonal imbalance causing the overgrowth. For women with atypical hyperplasia who desire fertility, intensive progestin-based therapy with close surveillance may be an option before considering hysterectomy.
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.