Recurrent Pregnancy Loss (RPL)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 11, 2026

Recurrent Pregnancy Loss (RPL) is defined as two or more clinical pregnancy losses before 20 weeks of gestation. RPL is clinically distinct from isolated early pregnancy loss: a single loss is common and often attributable to sporadic chromosomal error, while recurrent loss warrants systematic evaluation for treatable maternal and paternal contributors. Assessment includes peripheral karyotype analysis of both partners, antiphospholipid antibody testing, uterine anatomical evaluation (SHG, HSG, or hysteroscopy), thyroid and prolactin screening, and evaluation for hereditary thrombophilias. RRM pursues identification of underlying conditions including hormonal (progesterone deficiency, thyroid dysfunction), anatomical (isthmocele, septum, fibroids), immunologic (APS, NK cell activity), and metabolic factors. RPL affects an estimated 2 to 5% of couples attempting pregnancy.¹²

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.