Antiphospholipid Syndrome (APS)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 7, 2026

An autoimmune condition in which antiphospholipid antibodies (including lupus anticoagulant, anticardiolipin antibodies (aCL), and anti-beta-2 glycoprotein I antibodies) cause a hypercoagulable state that can result in thrombosis and pregnancy complications including recurrent miscarriage, fetal loss, and stillbirth. Diagnosis requires both clinical criteria (vascular thrombosis or pregnancy morbidity) and laboratory criteria (confirmed antibodies on two occasions 12 or more weeks apart). RRM treatment: low-dose aspirin initiated preconceptionally, plus prophylactic-dose heparin (LMWH) from a positive pregnancy test through delivery. Multiple guidelines (EULAR, ESHRE, ACCP, ACOG) support this protocol.⁵²³⁶

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.