Assisted reproductive technology and the risk of preeclampsia: an updated  systematic review and meta-analysis

Almasi-Hashiani A, Omani-Samani R, Mohammadi M, Amini P, Navid B, Alizadeh A, Khedmati Morasae E, Maroufizadeh S

doi:10.1186/s12884-019-2291-x

BMC Pregnancy and Childbirth, 19(1), 149, 2019

Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis

Amir Almasi‐Hashiani , Reza Omani‐Samani , Ahad Alizadeh

Author affiliations (8)

Arak University of Medical Sciences ROR
Royan Institute ROR
Ahvaz Jundishapur University of Medical Sciences ROR
University of Liverpool ROR
Guilan University of Medical Sciences ROR
Gerash University of Medical Sciences ROR
Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

DOI10.1186/s12884-019-2291-x PMID31046710

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Abstract

Background

The objective of this systematic review and meta-analyses was to assess the risk of preeclampsia among women who conceived with assisted reproductive technology (ART).

Methods

We searched the ISI Web of Knowledge, Medline/PubMed, Scopus, and Embase (from inception to May 2017) for English language articles using a list of key words. In addition, reference lists from identified studies and relevant review articles were also searched. Data extraction was performed by two authors, and the study quality was assessed using the Newcastle-Ottawa Scale. Random-effects model meta-analysis was applied to pool the relative risks (RR) across studies.

Results

A total of 48 studies (5 case-control studies and 43 cohort studies) were included in this meta-analysis. The Cochran Q test and I(2) statistics revealed substantial heterogeneity (Q = 26,313.92, d.f. = 47, p < 0.001 and I(2) = 99.8%). Meta-analysis showed a significant increase in preeclampsia in women who conceived by ART compared with those who conceived spontaneously (RR = 1.71, 95% CI = 1.11-2.62, p = 0.015).

Conclusions

The findings of this systematic review indicate that the use of ART treatment is associated with a 1.71-fold increase in preeclampsia.

Topics

Pregnancy Infertility

assisted reproductive technology preeclampsia, IVF preeclampsia risk, ART pregnancy complications, preeclampsia meta-analysis, IVF hypertensive disorders, ART adverse outcomes, preeclampsia risk factors, assisted conception complications, IVF maternal health, preeclampsia systematic review

PMID 31046710 31046710 DOI 10.1186/s12884-019-2291-x 10.1186/s12884-019-2291-x

Cite this article

Almasi-Hashiani, A., Omani-Samani, R., Mohammadi, M., Amini, P., Navid, B., Alizadeh, A., Khedmati Morasae, E., & Maroufizadeh, S. (2019). Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis. *BMC pregnancy and childbirth*, *19*(1), 149. https://doi.org/10.1186/s12884-019-2291-x

Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis

Abstract

Topics

Cite this article

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