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BACKGROUND: Endometriosis affects approximately 10% of women of reproductive age and is associated with increased risks of infertility and miscarriage. Although the spontaneous miscarriage rate in wom...

INTRODUCTION: Among the religious factors that significantly contribute to believers' well-being, research on the personal experience of divine forgiveness (DF) remains in its infancy. The aim of this...

BACKGROUND: Intrauterine insemination (IUI) is the first line treatment for conditions such as unexplained or mild male factor infertility. Endometrial thickness (EMT) is an important indicator for pr...

Ovarian hyperstimulation syndrome (OHSS) is a serious complication commonly encountered in patients with infertility undergoing ovulation induction therapy. This study investigates histomorphological ...

INTRODUCTION: The design and functionality of injection devices for controlled ovarian stimulation (COS) significantly influence dose accuracy and patient comfort, affecting adherence and treatment su...

PURPOSE: To evaluate the effectiveness and safety of the novel protocol-progestin-primed ovarian stimulation (PPOS) protocol during controlled ovarian hyperstimulation (COH), in patients undergoing in...

PURPOSE: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A...

Background & objectives Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterised by menstrual irregularities, hirsutism, acne, obesity, infertility, and other features adversely affec...

STUDY QUESTION: What are the effects of three-times-a-day 10 mg oral dydrogesterone (DYD), initiated in the late follicular phase of natural menstrual cycles to induce endometrial receptivity for froz...

During early pregnancy, human endometrial stromal cells differentiate into secretory decidual cells via a process regulated by ovarian steroid hormones. Decidual cells play a crucial role by secreting...

INTRODUCTION: Pincus and his group's initial research on hormonal contraception focused on progesterone. However, the natural compound could not be utilized in clinical practice because of the high in...

OBJECTIVE: The aim of this study was to investigate the effect of vaginal progesterone used to prevent spontaneous preterm birth in the development of gestational diabetes mellitus. METHODS: This is ...

INTRODUCTION: Insulin resistance and hyperinsulinaemia significantly influence female hormone regulation and reproductive health. Despite increasing research, the complex pathways by which nutritional...

BACKGROUND: Endometrial cancer (EC) is one of the most common cancers in women, with a short overall survival and poor prognosis. Besides the biologically aggressive EC properties, Cancer-associated c...

Large cell neuroendocrine carcinoma (LCNEC) of the endometrium is a rare and aggressive high-grade malignancy, constituting fewer than 1% of endometrial malignancies, with only 33 cases reported in th...

Sweden national IVF registry report covering 2023 treatments. 26,500 treatments started at 23 clinics (6 public, 17 private). 5,804 live born children (5,508 IVF + 296 IUI-D). Fresh IVF delivery rate ...

1. Define premature ovarian insufficiency, diagnostic criteria, risk factors and comorbidities. 2. Discuss health concerns, as well as health and hormone management of patients suffering with POI. 3. ...

Background: Chronic endometritis (CE), frequently asymptomatic, is associated with female infertility. Fallopian tube obstruction (FTO) is also one of the factors contributing to female infertility. M...

STUDY Question: How do endometriosis diagnoses and subtypes reported in administrative health data compare with surgically confirmed disease? SUMMARY ANSWER: For endometriosis diagnosis, we observed ...

STUDY Question: Can semen parameters predict long-term health outcomes in men? SUMMARY ANSWER: There is a lack of evidence to suggest a higher risk of comorbidities in men with poor semen concentrati...

The prevalence of uterine isthmocele, also known as a uterine niche, has risen in parallel with increasing cesarean section (CS) rates, affecting approximately 60% of women depending on their history ...

Background: Maternal hormonal contraception use has been associated with childhood leukemia risk. However, studies are few and often based on self-reported information. Methods: Using registry data f...

Study question: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed based on the best available evidence from published literature?Summary answerThe current guideline pro...

STUDY Question: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature? SUMMARY ANSWER: The current guidelin...

Background: The combined hormonal contraceptive (CHC) with ethinylestradiol and progestins is the most widely used contraceptive method among young women and is used by millions worldwide. However, un...

Background: Premature ovarian insufficiency/failure (POI/POF) is a significant issue for women of reproductive age. Anti-Müllerian hormone (AMH) is a potential biomarker of ovarian reserve, but its cl...

Objectives: To evaluate the experiences of perimenopausal and postmenopausal women in British Columbia, their perceptions of expected reproductive aging, and potential concerns about endometrial cance...

# Family formations in fertility treatment 2022 Preliminary UK family type statistics for IVF and DI treatment, storage, and donation Published: November 2024 [Download the underlying dataset as .xlsx...

STUDY Objective: To compare outcomes of vaginal surgery in women with moderate or severe symptomatic cesarean scar defect (with or without residual myometrium). Design: Retrospective cohort study. Set...

No standard criteria exist for how to perform a diagnostic laparoscopy. This case series provides evidence of the importance of standardized, reproducible techniques. A single non-oncologic gynecologi...

Full name: Systematic Mapping of the Abdomen and Pelvis (S-MAP). Attribution: method by Hilgers, term by Whittaker. Presented at AAGL 2024 (not ASRM). 4 cancers over 3 years (not 3 in 6 months).

# State of the fertility sector 2023/24 Annual publication on HFEA licensed clinics (1st April 2023 – 31st March 2024) Published: 1st October 2024 [Download the underlying dataset as .xlsx](https://ww...

Study Question: What is the relative length variance of the luteal phase compared to the follicular phase within healthy, non-smoking, normal-weight, proven normally ovulatory, premenopausal women wit...

STUDY Question: Are serum vitamin D levels associated with the incidence of endometrial polyps (EPs) in infertile patients? SUMMARY ANSWER: Serum 25(OH)D levels were nonlinearly correlated with the i...

STUDY Question: What are the roles of maternal preconception diabetes and related periconceptional hyperglycemia on the risk of major congenital malformations (MCMs) in offspring? SUMMARY ANSWER: Mat...

The primary purpose of this prospective cohort study was to determine if treating endometriosis with optimal excision surgery leads to lower rates of repeat surgery as compared to historical rates of ...

Introduction: Hormones produced by the hypothalamic-pituitary-adrenal-gonadal (HPAG) axis are crucial for modulating central nervous system (CNS) function and development throughout a person's life. D...

Background: The menstrual cycle is a critical indicator of women's health. Early prolonged secondary amenorrhea increases risks for morbidity and mortality. Menstrual cycle research in women with HIV ...

STUDY Question: Could the risk of subsequent pregnancy loss be predicted based on the risk factors of recurrent pregnancy loss (RPL) patients? SUMMARY ANSWER: A nomogram, constructed from independent...

Importance: Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and ovarian cancer histotypes have not been well-descri...

Background: The use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools. Objective: To investigate the associa...

Fertility awareness-based methods (FABMs), also known as natural family planning (NFP), enable couples to identify the days of the menstrual cycle when intercourse may result in pregnancy ("fertile da...

Purpose: It is asserted that primary dysmenorrhea/menstrual cramps only occur in ovulatory menstrual cycles. Our first objective was to present detailed menstrual cramps information in normally ovulat...

STUDY Question: What are the outcomes of pregnancies exposed to hydroxychloroquine (HCQ) in women with a history of recurrent pregnancy loss (RPL), and what factors predict the course of these pregnan...

# Fertility treatment 2022: preliminary trends and figures Preliminary UK statistics for IVF and DI treatment, storage, and donation Published: July 2024 [Download the underlying dataset as .xlsx](htt...

Background The increasing prevalence of cesarean section (CS) deliveries globally has sparked apprehension regarding potential long-term complications, notably the emergence of uterine niches. CS resu...