Heteromolecular Artimones (HMA)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 7, 2026

Heteromolecular artimones are synthetic compounds whose molecular structure has been altered from endogenous human hormones, coined by Dr. Thomas Hilgers as the antonym to isomolecular hormones. The term "artimone" signals "altered hormone." Examples include norethindrone, levonorgestrel, medroxyprogesterone acetate, and ethinyl estradiol, the active agents in most oral contraceptives and conventional hormone replacement formulations.⁷⁸

Hilgers argues that the molecular variance of heteromolecular artimones from endogenous hormones explains side-effect profiles that differ qualitatively, not just quantitatively, from isomolecular replacements. Synthetic progestins, for example, bind progesterone receptors but also bind androgen and glucocorticoid receptors. The downstream effects are not the same as endogenous progesterone.

In NaProTECHNOLOGY, heteromolecular artimones are never used in hormone replacement or supplementation protocols. CPRT, CERT, and pregnancy support protocols specify isomolecular compounds exclusively. The clinical distinction between these two pharmacological categories is foundational to Hilgers' approach to restorative hormone therapy. When oral contraceptives are discussed in the NaPro framework, Hilgers refers to their active compounds by this category name.

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.