The Journal of Clinical Endocrinology and Metabolism, 95(7), 3291-3299, 2010
A prospective exploration of cognitive dietary restraint, subclinical ovulatory disturbances, cortisol, and change in bone density over two years in healthy young women
Jerilynn C Prior, Susan I Barr, Jennifer L Bedford
Cross-sectional studies have found associations among elevated cognitive dietary restraint (CDR), increased ovulatory disturbances, and lower bone mass, possibly mediated by cortisol.
Objective
To determine whether healthy young women with higher CDR have more menstrual cycles with subclinical ovulatory disturbances (SOD), elevated 24-h urinary free cortisol (UFC), and less positive 2-yr areal bone mineral density change (Delta-aBMD). DESIGN, SETTING, AND
Participants
We conducted a 2-yr longitudinal study of 123 healthy, community-dwelling, nonobese, regularly menstruating women aged 19-35 yr.
Main Outcome Measures
Key variables were Three Factor Eating Questionnaire Restraint score, percent of cycles with anvoluation and/or luteal phase length <10 d (%SOD), UFC, and Delta-aBMD at the lumbar spine (L1-L4), total hip, and whole body. Anthropometrics, general stress, physical activity, and energy intake were measured. Adjusting for potential confounders, differences were examined by general linear modeling using median split of CDR score and %SOD.
Results
Women with higher CDR had higher %SOD (56 vs. 34%, P < 0.001) and higher UFC (28.0 vs. 24.0 microg/d, P = 0.021). Delta-aBMD did not differ by CDR. Women with higher %SOD had less positive Delta-aBMD at L1-L4 (0.7 vs. 1.9%, P = 0.034) and hip (-0.6 vs. 0.9%, P = 0.001), and higher CDR score (8.7 vs. 7.1, P = 0.04). Physical activity, general stress, body mass index, and energy intake did not explain differences by CDR or %SOD. UFC was not associated with %SOD or Delta-aBMD.
Conclusion
Women with more frequent SOD reported higher CDR and experienced less positive Delta-aBMD. Although women with higher CDR had higher UFC, the mechanism linking CDR, SOD, and aBMD is not clear.
cognitive dietary restraint subclinical ovulatory disturbances bone density, Prior JC ovulatory disturbances bone mineral density premenopausal, anovulation short luteal phase bone loss young women prospective, cortisol urinary free cortisol ovulation disturbances dietary restraint, subclinical ovulatory disturbances lumbar spine hip bone density change, eating behavior menstrual cycle disruption premenopausal women longitudinal, basal body temperature ovulation detection bone mineral density, Bedford Prior Barr dietary restraint ovulation prospective cohort, luteal phase deficiency bone density two year longitudinal study, cognitive dietary restraint cortisol mediation reproductive function
PMID 20427503 20427503 DOI 10.1210/jc.2009-2497 10.1210/jc.2009-2497
Cite this article
Bedford, J. L., Prior, J. C., & Barr, S. I. (2010). A prospective exploration of cognitive dietary restraint, subclinical ovulatory disturbances, cortisol, and change in bone density over two years in healthy young women. The Journal of clinical endocrinology and metabolism, 95(7), 3291-3299. https://doi.org/10.1210/jc.2009-2497
Bedford JL, Prior JC, Barr SI. A prospective exploration of cognitive dietary restraint, subclinical ovulatory disturbances, cortisol, and change in bone density over two years in healthy young women. J Clin Endocrinol Metab. 2010;95(7):3291-3299. doi:10.1210/jc.2009-2497
Bedford, J. L., et al. "A prospective exploration of cognitive dietary restraint, subclinical ovulatory disturbances, cortisol, and change in bone density over two years in healthy young women." The Journal of clinical endocrinology and metabolism, vol. 95, no. 7, 2010, pp. 3291-3299.
Keywords
Hydrocortisone
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