Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone participate in the pathogenesis of breast cancer.
estrogen breast cancer mechanism, hormonal carcinogenesis breast tissue, estrogen metabolites dna damage, genotoxic effects estrogen, hormone replacement therapy cancer risk, estrogen receptor breast cancer pathogenesis, synthetic estrogen carcinogenic effects, hormonal contraception breast cancer, estrogen-induced mutations breast
Cite this article
Yager, J. D., & Davidson, N. E. (2006). Estrogen carcinogenesis in breast cancer. *The New England journal of medicine*, *354*(3), 270-282. https://doi.org/10.1056/NEJMra050776
Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006;354(3):270-282. doi:10.1056/NEJMra050776
Yager, James D., and Nancy E. Davidson. "Estrogen carcinogenesis in breast cancer." *The New England journal of medicine*, vol. 354, no. 3, 2006, pp. 270-282.
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