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C-reactive protein in preterm premature rupture of the membranes

Jorma Paavonen, T Kurki, K Teramo, O Ylikorkala

  • Turku University Hospital ROR
  • Helsinki University Hospital ROR

Archives of Gynecology and Obstetrics, 247(1), 31-37

DOI 10.1007/BF02390652 PMID 2353964

Abstract

The usefulness of maternal C-reactive protein (CRP) measurements in the diagnosis of chorioamnionitis and puerperal and neonatal infectious morbidity was studied among 147 patients with preterm rupture of the membranes (PROM). Thirty-three patients developed chorioamnionitis, 10 patients developed puerperal endometritis, and 21 newborn infants developed neonatal infections. There was no difference in the highest antepartum CRP between patients with or without chorioamnionitis. The overall test performance for CRP was poor suggesting that elevated antepartum CRP may be misleading in the diagnosis of chorioamnionitis. However, use of serial CRP measurements increases the test performance. The high negative predictive value suggests that CRP is useful in predicting the absence of chorioamnionitis.

Topics

Pregnancy > Preterm Birth > Premature Rupture of MembranesDiagnostics > Biomarkers > C-Reactive Protein in PregnancyPregnancy > Complications > Chorioamnionitis Diagnosis
C-reactive protein preterm premature rupture membranes, CRP chorioamnionitis diagnosis PROM, serial CRP measurements preterm PROM infection prediction, maternal CRP puerperal endometritis neonatal infection, preterm rupture membranes inflammatory markers diagnosis, CRP negative predictive value chorioamnionitis absence, Kurki Paavonen CRP preterm PROM, infection biomarkers premature rupture membranes management, antepartum CRP test performance chorioamnionitis, neonatal infectious morbidity preterm PROM prediction
PMID 2353964 2353964 DOI 10.1007/BF02390652 10.1007/BF02390652

Cite this article

Kurki, T., Teramo, K., Ylikorkala, O., & Paavonen, J. (1990). C-reactive protein in preterm premature rupture of the membranes. *Archives of gynecology and obstetrics*, *247*(1), 31-37. https://doi.org/10.1007/BF02390652

Keywords

Adult, Biomarkers/analysis, C-Reactive Protein/analysis, Chorioamnionitis/diagnosis, Endometritis/diagnosis, Female, Fetal Membranes, Premature Rupture/etiology, Humans, Infant, Newborn, Infant, Premature, Diseases/diagnosis, Pregnancy, Puerperal Infection/diagnosis/etiology, Biomarkers, C-Reactive Protein

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