Abstract
Objective To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E2, FSH, LH, and T.
Design Controlled prospective study.
Setting University research laboratory.
ANIMAL(S): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age.
INTERVENTION(S): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 microg/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized.
MAIN OUTCOME MEASURE(S): Number of mature follicles, endometrial thickness, and serum levels of hormones.
RESULT(S): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ.
CONCLUSION(S): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate.
letrozole versus clomiphene citrate rat model ovarian follicles, aromatase inhibitor clomiphene endometrial thickness comparison, letrozole effect on endometrium animal study, clomiphene citrate anti-estrogenic endometrial effects, letrozole ovulation induction follicular maturation, Kilic-Okman letrozole clomiphene rat comparison, aromatase inhibitor FSH LH estradiol levels, clomiphene versus letrozole hormone levels animal model, controlled prospective study letrozole ovarian response, letrozole endometrial receptivity compared clomiphene
PMID 14667861 14667861 DOI 10.1016/j.fertnstert.2003.05.002 10.1016/j.fertnstert.2003.05.002
Keywords
Animals, Cell Count, Clomiphene/pharmacology, Endometrium/drug Effects/physiology, Estradiol/blood, Female, Fertility Agents, Female/pharmacology, Follicle Stimulating Hormone/blood, Letrozole, Luteinizing Hormone/blood, Nitriles/pharmacology, Ovarian Follicle/cytology/drug Effects/physiology, Rats, Rats, Wistar, Reference Values, Testosterone/blood, Triazoles/pharmacology, Fertility Agents, Female, Nitriles, Triazoles, Clomiphene, Testosterone, Estradiol, Letrozole, Luteinizing Hormone, Follicle Stimulating Hormone