Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study

Iñaki Lete; Nicolás Mendoza; Esther de la Viuda; Francisco Carmona

doi:10.1016/j.ejogrb.2018.07.002

General Gynecology · Pelvic Pain

Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study

Lete I, Mendoza N, de la Viuda E, Carmona F

Published September 2018 European journal of obstetrics, gynecology, and reproductive biology, 228, 221-224

DOI 10.1016/j.ejogrb.2018.07.002 PMID 30007250

Abstract

Objective

To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain.

Study Design

Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain.

Results

In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7% of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months of treatment, this percentage decreased to 87.2% (p = 0.074) and at 6 months the percentage was 82.7% (p < 0.05).

Conclusions

Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.

Topics

General Gynecology Pelvic Pain Chronic Pelvic Pain

General Gynecology › Pelvic Pain › Chronic Pelvic Pain

Iñaki Lete, Nicolás Mendoza, Esther de la Viuda, Francisco Carmona

I Lete, N Mendoza, E Viuda, F Carmona

PMID 30007250 30007250 DOI 10.1016/j.ejogrb.2018.07.002 10.1016/j.ejogrb.2018.07.002 Lete et al. 2018, Lete 2018

Keywords

Alpha lipoic acid, Antioxidants, Bromelain, Endometriosis-associated pelvic pain, N-Acetyl cysteine

Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study

Abstract

Topics

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Keywords