Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

Letizia Chiara Pezzaioli; Elisa Gatta; Francesca Bambini; Paolo Facondo; Maria Gava; Maria Cavadini; Caterina Buoso; Elena Di Lodovico; Mario Rotondi; Alberto Ferlin; Carlo Cappelli

doi:10.3389/fendo.2022.1027047

Autoimmune and Inflammatory Disease · Autoimmune Conditions

Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

Pezzaioli LC, Gatta E, Bambini F, Facondo P, Gava M, Cavadini M, Buoso C, Di Lodovico E, Rotondi M, Ferlin A, Cappelli C

Published November 10, 2022 Frontiers in endocrinology

DOI 10.3389/fendo.2022.1027047 PMID 36440218 PMC PMC9685624

Abstract

Purpose

The purpose of this study was to describe the current knowledge on the potential endocrine adverse effects post-COVID-19 vaccines.

Methods

A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies, and reviews written in English and published online up to 31 July 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.

Results

The available data showed that endocrine side effects are generally rare and with favorable outcome, being thyroid disorders the most common. Conversely, data on type 1 diabetes mellitus are rare; adrenal and pituitary events are even anecdotal. Finally, the available clinical studies suggest no impact on female reproductive system and on male and couple fertility.

Conclusion

Overall, these data show that, after 2 years of COVID-19 vaccines, the endocrine system is not heavily threatened.

Topics

Autoimmune and Inflammatory Disease Autoimmune Conditions Autoimmune Thyroid Disease

Autoimmune and Inflammatory Disease › Autoimmune Conditions › Autoimmune Thyroid Disease

Letizia Chiara Pezzaioli, Elisa Gatta, Francesca Bambini, Paolo Facondo, Maria Gava, Maria Cavadini, Caterina Buoso, Elena Di Lodovico, Mario Rotondi, Alberto Ferlin, Carlo Cappelli

L Pezzaioli, E Gatta, F Bambini, P Facondo, M Gava, M Cavadini, C Buoso, E Lodovico, M Rotondi, A Ferlin, C Cappelli

PMID 36440218 36440218 DOI 10.3389/fendo.2022.1027047 10.3389/fendo.2022.1027047 Pezzaioli et al. 2022, Pezzaioli 2022

Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

Abstract

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