Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes

Beate Stiemer; Anke Buschmann; Susanne Bisson; Karin Hensel; Hans-Joachim Gramm; Hartmut Hopp; Hans-Karl Weitzel

doi:10.1111/j.1471-0528.1997.tb11504.x

Research Methods · Preclinical Research

Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes

Stiemer B, Buschmann A, Bisson S, Hensel K, Gramm HJ, Hopp H, Weitzel HK

Published April 1997 British Journal of Obstetrics and Gynaecology, 104(4), 499-502

DOI 10.1111/j.1471-0528.1997.tb11504.x PMID 9141589

Abstract

Interleukin-8 (IL-8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL-8 was detected in the urine of 91 of 104 women with premature rupture of the fetal membranes, with values exceeding 1000 ng/L in cases of severe intra-amniotic infection. Women with urinary tract infections were excluded. The routine measurement of IL-8 in urine, together with C-reactive protein in serum, thus provides a low risk and technically simple approach to the assessment of intra-amniotic infection.

Topics

Research Methods › Preclinical Research › Laboratory Methods · General Gynecology › Infections › Pelvic Inflammatory Disease · Pregnancy › Pregnancy Complications › Intrauterine Infection

Beate Stiemer, Anke Buschmann, Susanne Bisson, Karin Hensel, Hans-Joachim Gramm, Hartmut Hopp, Hans-Karl Weitzel

B Stiemer, A Buschmann, S Bisson, K Hensel, H Gramm, H Hopp, H Weitzel

PMID 9141589 9141589 DOI 10.1111/j.1471-0528.1997.tb11504.x 10.1111/j.1471-0528.1997.tb11504.x Stiemer et al. 1997, Stiemer 1997

Keywords

Amnion, Enzyme-Linked Immunosorbent Assay, Female, Fetal Membranes, Premature Rupture/urine, Humans, Interleukin-8/urine, Pregnancy, Pregnancy Complications, Infectious/diagnosis, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prenatal Diagnosis/methods, Sensitivity and Specificity, Interleukin-8

Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes

Abstract

Topics

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Keywords