Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions

Estil Y. Strawn; David Bick; Amy Swanson

doi:10.1016/j.fertnstert.2010.01.067

Assisted Reproduction · Safety and Risks

Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions

Strawn EY, Bick D, Swanson A

Published July 2010 Fertility and Sterility, 94(2), 754.e1-754.e2

DOI 10.1016/j.fertnstert.2010.01.067

Abstract

Objective

To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility.

Design

Case report.

Setting

Academic medical center.

Patients

Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient.

Interventions

Assisted reproductive technology.

Main Outcome Measures

Neonatal and pediatric morphologic evaluation by geneticists.

Results

Two children with the morphologic features consistent with the criteria for the diagnosis of BWS.

Conclusions

Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms.

Topics

Assisted Reproduction › Safety and Risks › Birth Defects · Genetics and Immunology › Reproductive Genetics › Epigenetics

Estil Y. Strawn, David Bick, Amy Swanson

E Strawn, Dave Bick, D Bick, A Swanson

DOI 10.1016/j.fertnstert.2010.01.067 10.1016/j.fertnstert.2010.01.067 Strawn et al. 2010, Strawn 2010

Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions

Abstract

Topics

By this author

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