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Assisted Reproduction · Safety and Risks

Meta-analysis of cancer incidence in children born after assisted reproductive technologies

Raimondi S, Pedotti P, Taioli E

Published October 31, 2005 British journal of cancer, 93(9), 1053-6
DOI 10.1038/sj.bjc.6602838 PMID 16234814 PMC PMC2361681

Abstract

A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62-2.85), and 0.77 (95% CI 0.41-1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.

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Assisted Reproduction › Safety and Risks › Long Term Child Outcomes · Research Methods › Evidence Synthesis › Meta-Analysis
PMID 16234814 16234814 DOI 10.1038/sj.bjc.6602838 10.1038/sj.bjc.6602838 Raimondi et al. 2005, Raimondi 2005

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