Communications Biology, 2026
Abstract
Anti-Müllerian hormone (AMH), produced by ovarian granulosa cells, is a key regulator of female reproduction. Traditionally seen as a local follicular brake, emerging evidence calls for a paradigm shift. We propose that AMH acts as a context-dependent signaling hub. It primarily signals via the Smad1/5/8 pathway and interacts with Wnt/β-catenin and MAPK cascades to regulate follicle growth and steroidogenesis. Beyond the ovary, AMH and its receptors are expressed in the hypothalamus, pituitary, uterus, and placenta, modulating the hypothalamic-pituitary-gonadal axis and other reproductive processes. This review provides a comprehensive framework for understanding AMH as a context-dependent signaling hub in female mammals.
Topics
PMID 42135492 42135492 DOI 10.1038/s42003-026-10273-1 10.1038/s42003-026-10273-1 Li et al. 2026, Li 2026
Cite this article
Li, J., Zhu, W., Bu, Y., Li, L., Wei, H., & Zhang, S. (2026). Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction. Communications Biology. https://doi.org/10.1038/s42003-026-10273-1
Li J, Zhu W, Bu Y, Li L, Wei H, Zhang S. Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction. Communications Biology. 2026. doi:10.1038/s42003-026-10273-1
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