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Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length

Shirin Kalyan, Arianne Y K Albert, Deborah Money, Evelyn J Maan, Hélène C F Côté, Melanie C M Murray, Neora Pick, Jerilynn C Prior, Alice Mai, Kristen Kidson, Jackson Chu, Azita Goshtasebi

Open Access
  • University of British Columbia ROR
  • Women's Health Research Institute ROR
  • B.C. Women's Hospital & Health Centre ROR
  • Vancouver Hospital and Health Sciences Centre ROR
  • Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada

Int J Environ Res Public Health, 15(5), E1018

DOI 10.3390/ijerph15051018 PMID 29783641

Abstract

With advances in combination antiretroviral therapy (cART), people living with HIV are now surviving to experience aging. Evidence suggests that individuals living with HIV are at greater risk for low bone mineral density (BMD), osteoporosis, and fractures. Better understanding of the pathophysiology of bone health in women living with HIV (WLWH) is important for treatment strategies. The goal of this study was to explore new biological factors linked to low BMD in WLWH. Standardized BMD measures of WLWH were compared to reference values from an unselected population of women from the same geographical region of the same age range. Linear regression analysis was used to assess relationships among health-related characteristics, cellular aging (measured by leukocyte telomere length; LTL), cART, and BMD of WLWH. WLWH (n = 73; mean age 43 ± 9 years) had lower BMD Z-scores at the lumbar spine (LS) (mean difference = -0.39, p p = 0.012) relative to controls (n = 290). WLWH between 50 and 60 years (n = 17) had lower Z-scores at the LS (p = 0.008) and TH (p = 0.027) compared to controls (n = 167). Among WLWH, LS BMD was significantly associated with LTL (R² = 0.09, p = 0.009) and BMI (R² = 0.06, p = 0.042). Spinal BMD was adversely affected in WLWH. Reduction of LTL was strongly associated with lower BMD and may relate to its pathophysiology and premature aging in WLWH.

Topics

Bone Health > HIV-Associated > Premature Spinal Bone LossPerimenopause/Menopause > Premature Aging > HIV and Telomere ShorteningResearch Methodology > Cross-Sectional Study > HIV Bone-Telomere Association
Kalyan Pick Mai Murray Prior HIV spinal bone loss leukocyte telomere length women, premature bone loss women HIV antiretroviral therapy telomere shortening association, combination antiretroviral therapy cART bone mineral density osteoporosis HIV aging, leukocyte telomere length biological aging HIV women spinal BMD accelerated loss, International Journal Environmental Research Public Health 2018 HIV bone telomere, low BMD fracture risk women living with HIV premature aging immunosenescence, spinal vertebral bone loss HIV women cART telomere shortening biological marker, HIV accelerated aging bone density telomere length cross-sectional association, antiretroviral therapy bone toxicity tenofovir efavirenz protease inhibitor effects, osteoporosis risk women HIV shorter telomeres premature spinal bone loss
PMID 29783641 29783641 DOI 10.3390/ijerph15051018 10.3390/ijerph15051018

Cite this article

Shirin Kalyan, Neora Pick, Alice Mai, Melanie C M Murray, Kristen Kidson, Jackson Chu, Arianne Y K Albert, Hélène C F Côté, Evelyn J Maan, Azita Goshtasebi, Deborah M Money, & Jerilynn C Prior (2018). Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length. *International journal of environmental research and public health*, *15*(5), E1018. https://doi.org/10.3390/ijerph15051018

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