Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle

James R Stelling; Emily T Chapman; David Frankfurter; Doria H Harris; Selwyn P Oskowitz; Richard H Reindollar

doi:10.1016/s0015-0282(02)04918-x

Reproductive Endocrinology Ovarian Hormones

Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle

Stelling JR, Chapman ET, Frankfurter D, Harris DH, Oskowitz SP, Reindollar RH

Published April 2003 Fertility and Sterility, 79(4), 881-885

DOI 10.1016/s0015-0282(02)04918-x PMID 12749424

Abstract

Objective

To confirm that hCG levels in follicular fluid and serum would be comparable between i.m. and s.c. administration of purified hCG.

Design

In a prospective study, serum and follicular fluid levels of hCG after an i.m. or s.c. injection of 10,000 IU of hCG were evaluated 36 hours after injection, that is, at the time of oocyte retrieval.

Setting

This study was carried out in a university-affiliated IVF program.

Patients

Forty women undergoing oocyte retrieval were entered into the study at the time of egg retrieval, that is, 36 hours after hCG administration.

Interventions

S.c. or i.m. injection of hCG.

Main Outcome Measures

Serum and follicular fluid concentrations of hCG were evaluated 36 hours after injection at the time of oocyte retrieval.

Results

There was a significantly higher serum hCG level in the s.c. group (348.6 +/- 98 IU/L) vs. the i.m. group (259.0 +/- 115 IU/L) and a significantly higher follicular fluid hCG level in the s.c. vs. the i.m. group (233.5 +/- 85 vs. 143.4 +/- 134 IU/L).

Conclusions

After purified hCG administration via the s.c. route, both serum and follicular fluid levels are greater compared with the i.m. route.

Topics

Reproductive Endocrinology › Ovarian Hormones › Progesterone · Therapeutics › Hormonal Agents › Gonadotropins · Assisted Reproduction › Procedures and Protocols › Ovarian Stimulation

James R Stelling, Emily T Chapman, David Frankfurter, Doria H Harris, Selwyn P Oskowitz, Richard H Reindollar

Jim Stelling, Jimmy Stelling, J Stelling, E Chapman, Dave Frankfurter, D Frankfurter, D Harris, S Oskowitz, Rick Reindollar, Dick Reindollar, Rich Reindollar, R Reindollar

PMID 12749424 12749424 DOI 10.1016/s0015-0282(02)04918-x 10.1016/s0015-0282(02)04918-x Stelling et al. 2003, Stelling 2003

Keywords

Adult, Chorionic Gonadotropin/administration & Dosage/blood/metabolism, Female, Fertilization in Vitro/methods, Follicle Stimulating Hormone/metabolism, Follicular Fluid/metabolism, Humans, Injections, Intramuscular, Injections, Subcutaneous, Ovarian Follicle/metabolism, Ovulation Induction/methods/standards, Pregnancy, Prospective Studies, Chorionic Gonadotropin, Follicle Stimulating Hormone

Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle

Abstract

Topics

By this author

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Keywords