The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume

Eden JA; Place J; Carter GD; Jones J; Alaghband-Zadeh J; Pawson ME

Reproductive Endocrinology · Ovarian Hormones

The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume

Eden JA, Place J, Carter GD, Jones J, Alaghband-Zadeh J, Pawson ME

Published February 1989 Obstetrics and Gynecology, 73(2), 187-190

PMID 2492092

Abstract

Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.

Topics

Reproductive Endocrinology › Ovarian Hormones › Estrogen · Menstrual Cycle › Cycle Physiology › Follicular Phase · Diagnostics › Endometrial Assessment › Receptivity Testing

PMID 2492092 2492092 Eden et al. 1989, Eden 1989

Keywords

Adult, Clomiphene/therapeutic Use, Endometrium/drug Effects, Estrogens/blood, Female, Follicle Stimulating Hormone/blood, Follicular Phase/drug Effects, Humans, Luteinizing Hormone/blood, Ovulation Induction, Testosterone/blood, Ultrasonography, Uterus/drug Effects, Estrogens, Clomiphene, Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone

The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume

Abstract

Topics

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Keywords