Nordio, M., & Basciani, S. (2017). Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis. International Journal of Endocrinology, 2017, 2549491. https://doi.org/10.1155/2017/2549491
Nordio M, Basciani S. Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis. Int J Endocrinol. 2017;2017:2549491. doi:10.1155/2017/2549491
Nordio, Maurizio, and Sabrina Basciani. "Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis." International Journal of Endocrinology, vol. 2017, 2017, pp. 2549491.
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Myo-inositol plus selenium lowered TSH over 6 months in Hashimoto's
A single-group study of 86 adults with Hashimoto's thyroiditis and subclinical hypothyroidism found that myo-inositol plus selenium lowered TSH and both thyroid antibodies over 6 months. Free thyroid hormones rose slightly, and symptom scores improved. One patient with hyperthyroidism also had TSH return to normal.
Key Findings
Thyroid-stimulating hormone (TSH) fell significantly after 6 months of myo-inositol plus selenium in the 86 patients with Hashimoto's thyroiditis and subclinical hypothyroidism (p ≤ 0.001).
Antithyroglobulin (TgAb) and antithyroid peroxidase (TPOAb) antibody levels both decreased (p ≤ 0.001 for each). Free T3 rose slightly but significantly (p ≤ 0.01), as did free T4 (p ≤ 0.001).
The subjective symptom score, from a 7-question symptom questionnaire, dropped from 4.67 to 2.37 across 87 patients (p ≤ 0.001).
One woman with hyperthyroidism, enrolled as a single case, had TSH rise from a low baseline into the normal range after 6 months.
The authors report an absence of side effects.
Interpretation
This report describes a single-group before-and-after study. All 87 participants took myo-inositol plus selenium for 6 months, and paired t-tests compared each person's baseline with the 6-month result. Participants were adults aged 19 to 65, mostly women, and the 86 with Hashimoto's thyroiditis had normal free thyroid hormone levels at the start. The authors note that the hyperthyroid result comes from one patient and call for a larger group. The findings support larger studies of myo-inositol and selenium in autoimmune thyroiditis.
RRM Context
The paper links myo-inositol to the signaling of insulin, follicle-stimulating hormone and TSH. These hormones shape both metabolic and reproductive function. Restorative reproductive medicine asks why a hormone system is out of balance and works on the underlying cause. Thyroid regulation, the target of this study, sits within that question.
Our editorial summary of this paper, not the article's abstract.
Abstract
Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto's thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6 mIU/L, elevated serum antithyroid peroxidase (TPOAb) and/or antithyroglobulin (TgAb), and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels were enrolled in the study: one hyperthyroid subject with TSH about 0.14 μU/ml was included in this trial as a single case. Patients were assigned to receive Myo-Ins-Se. TSH, TPOAb, and TgAb levels were significantly decreased in patients treated with combined Myo-Ins-Se after 6 months of treatment. In addition, a significant fT3 and fT4 increase, along with an amelioration of their quality of life, was observed. Remarkably, TSH values of the hyperthyroid patient increased from 0.14 μU/ml up to 1.02 μU/ml, showing a complete restoration of TSH values at a normal range. In conclusion, the administration of Myo-Ins-Se is significantly effective in decreasing TSH, TPOAb, and TgAb levels, as well as enhancing thyroid hormones and personal wellbeing, therefore restoring euthyroidism in patients diagnosed with autoimmune thyroiditis.
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