Account

Validity of the association between periodontitis and female infertility conditions: a concise review

Machado V, Lopes J, Patrão M, Botelho J, Proença L, Mendes JJ

Published September 2020 Reproduction (Cambridge, England), 160(3), R41-R54
DOI 10.1530/REP-20-0176 PMID 32716008

Abstract

Hormones and inflammatory mechanisms are implicated with female reproductive function, including follicle maturation, ovulation, embryo implantation, and pregnancy. Periodontitis is a chronic inflammatory disease due to a polymicrobial disruption of the homeostasis and may be considered as a potential risk factor that affect female fertility. The role of periodontitis is becoming meaningful, with significant associations with polycystic ovary syndrome, endometriosis and bacterial vaginosis. Further, periodontitis is linked with known risk factors towards female infertility, such as age, obesity, and chronic kidney disease. This review aims to summarize the available evidence on the association between periodontitis and female infertility-associated conditions, and to discuss warranting steps in future research.

Related research

Vanessa Machado, Joana Lopes, Mariana Patrão, João Botelho, Luís Proença, José João Mendes
V Machado, J Lopes, M Patrão, J Botelho, L Proença, J Mendes
PMID 32716008 32716008 DOI 10.1530/REP-20-0176 10.1530/REP-20-0176 Machado et al. 2020, Machado 2020

Learn

Resources

Tools

Help

Candid Platinum Transparency 2026

RRM Academy is a 501(c)(3) nonprofit providing free and low-cost education in restorative reproductive medicine for patients and healthcare professionals.

This site is an educational resource and does not provide medical advice. Inclusion of a study does not imply endorsement of its findings. Always consult a qualified healthcare provider for diagnosis and treatment.

© 2026 RRM Academy · All Rights Reserved

Restorative Reproductive Medicine Foundation · 3401 Hartzdale Dr, Ste 103B PMB 3518, Camp Hill, PA 17011 · EIN: 93-4594315
Sitemap AI Instructions Developers Terms of Use Medical Disclaimer Privacy Policy