Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?
Ian Hammond, S M Kaiser, Andy Kin On Wong
Angela M Cheung, Brian C Lentle, Christopher S Kovacs, Claudie Berger, David A Hanley, David Goltzman, J P Brown, Jonathan D Adachi, Linda Probyn, Lisa Langsetmo, Jerilynn C Prior, Robert G Josse, Stephanie M Kaiser, Tanveer Towheed, William D Leslie, Jeff Hu
Study purposeMorphometric methods categorize potential osteoporotic vertebral fractures (OVF) on the basis of loss of vertebral height. A particular example is the widely used semiquantitative morphometric tool proposed by Genant (GSQ). A newer morphologic algorithm-based qualitative (mABQ) tool focuses on vertebral end-plate damage in recognizing OVF. We used data from both sexes in the Canadian Multicentre Osteoporosis Study (CaMos) to compare the 2 methods in identifying OVF at baseline and during 10 years of follow-up.
Materials and Methods
We obtained lateral thoracic and lumbar spinal radiographs (T4-L4) 3 times, at 5-year intervals, in 828 participants of the population-based CaMos. Logistic regressions were used to study the association of 10-year changes in bone mineral density (BMD) with incident fractures.
Results
At baseline, 161 participants had grade 1 and 32 had grade 2 GSQ OVF; over the next 10 years, only 9 of these participants had sustained incident GSQ OVF. Contrastingly, 21 participants at baseline had grade 1 and 48 grade 2 mABQ events; over the next 10 years, 79 subjects experienced incident grade 1 or grade 2 mABQ events. Thus, incident grades 1 and 2 morphologic fractures were 8 times more common than morphometric deformities alone. Each 10-year decrease of 0.01 g/cm2 in total hip BMD was associated with a 4.1% (95% CI: 0.7-7.3) higher odds of having an incident vertebral fracture.
Conclusions
This analysis further suggests that morphometric deformities and morphologic fractures constitute distinct entities; morphologic fractures conform more closely to the expected epidemiology of OVF.
vertebral fracture radiological criteria morphometric morphologic, Genant semiquantitative morphometric vertebral fracture classification, algorithm-based qualitative mABQ vertebral fracture assessment, Prior JC CaMos vertebral fracture bone mineral density, osteoporotic vertebral fracture endplate damage identification, Lentle morphologic algorithm vertebral fracture detection, BMD change incident vertebral fracture prediction longitudinal, Canadian Multicentre Osteoporosis Study vertebral fracture, morphometric deformity versus morphologic fracture distinction, total hip BMD vertebral fracture odds longitudinal cohort
PMID 32755312 32755312 DOI 10.1177/0846537120943529 10.1177/0846537120943529
Cite this article
Brian C Lentle, Claudie Berger, Jacques P Brown, Linda Probyn, Lisa Langsetmo, Ian Hammond, Jeff Hu, William D Leslie, Jerilynn C Prior, David A Hanley, Jonathan D Adachi, Robert G Josse, Angela M Cheung, Stephanie M Kaiser, Tanveer Towheed, Christopher S Kovacs, Andy Kin On Wong, & David Goltzman (2021). Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?. *Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes*, *72*(1), 150-158. https://doi.org/10.1177/0846537120943529
Brian C Lentle, Claudie Berger, Jacques P Brown, Linda Probyn, Lisa Langsetmo, Ian Hammond, et al. Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?. Can Assoc Radiol J. 2021;72(1):150-158. doi:10.1177/0846537120943529
Brian C Lentle, et al. "Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?." *Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes*, vol. 72, no. 1, 2021, pp. 150-158.
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