Premature Ovarian Insufficiency (POI)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 7, 2026

Loss of normal ovarian function before age 40, resulting in irregular or absent menstruation, infertility, and hormonal deficiencies mimicking menopause. Formerly known as Premature Ovarian Failure (POF); the contemporary term reflects that ovarian function may be intermittent rather than fully absent. Affects approximately 1% of women under 40. Causes include autoimmune, genetic (fragile X premutation), iatrogenic (chemotherapy, radiation), and idiopathic. RRM evaluation and management includes hormone replacement therapy, fertility-preservation strategies, and treatment of underlying autoimmune conditions.³

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