Use of clomiphene citrate in women
Infertility > Ovulation Induction > Clomiphene CitrateInfertility > Medical Treatment > Practice GuidelinesPCOS > Treatment > Ovulation Induction
A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction
Fertility and Sterility, 75(5), 1024-1026
DOI 10.1016/s0015-0282(01)01749-6 PMID 11334921
Abstract
Objective
To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.
Design
Prospective randomized trial.
Setting
Infertility clinic in a university teaching hospital.
PATIENT(S): Eighty-six anovulatory women under 40 years of age undergoing ovulation induction.
INTERVENTION(S): The women were assigned randomly to receive either TMX or CC on cycle days 5-9.
MAIN OUTCOME MEASURE(S): Rates of ovulation and pregnancy for the two treatment modalities.
RESULTS(S): The overall rate of ovulation in the TMX group was 50 of 113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in the TMX group and 6 pregnancies in the CC group. The cycle fecundity per ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.
CONCLUSION(S): The overall rate of ovulation and pregnancy were similar with TMX and CC. TMX is a suitable alternative agent to CC in the management of anovulatory infertility.
Topics
Cite this article
Boostanfar, R., Jain, J. K., Mishell DR Jr, & Paulson, R. J. (2001). A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction. *Fertility and sterility*, *75*(5), 1024-1026. https://doi.org/10.1016/s0015-0282(01)01749-6
Boostanfar R, Jain JK, Mishell DR Jr, Paulson RJ. A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction. Fertil Steril. 2001;75(5):1024-1026. doi:10.1016/s0015-0282(01)01749-6
Boostanfar, R., et al. "A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction." *Fertility and sterility*, vol. 75, no. 5, 2001, pp. 1024-1026.
Keywords
Adult, Clomiphene/administration & Dosage/therapeutic Use, Female, Humans, Infertility, Female/drug Therapy, Luteinizing Hormone/urine, Male, Ovulation Induction/methods, Pregnancy, Pregnancy Rate, Prospective Studies, Selective Estrogen Receptor Modulators/administration & Dosage/therapeutic Use, Tamoxifen/administration & Dosage/therapeutic Use, Selective Estrogen Receptor Modulators, Tamoxifen, Clomiphene, Luteinizing Hormone