Women experiencing recurrent spontaneous abortion have a higher frequency of infertility than that expected in the general population. To further define the relationships between infertility and spontaneous abortion, the obstetrical histories of 43 women with unexplained secondary infertility were evaluated for the frequency of spontaneous abortion. Of the 88 pregnancies studied, 39 (44%) resulted in spontaneous abortion. Women with unexplained secondary infertility experienced a three-fold increase (P less than 0.0001) in the frequency of spontaneous abortions and half the number of live births (P less than 0.0001) compared with the general population. We conclude that the association between infertility and spontaneous abortion includes a higher frequency of spontaneous abortion among infertile couples as well as a higher prevalence of infertility among recurrent spontaneous aborters compared with the general population.
recurrent spontaneous abortion infertility association, unexplained secondary infertility miscarriage rate, Coulam infertility spontaneous abortion immunology, recurrent pregnancy loss infertility frequency relationship, unexplained infertility higher spontaneous abortion risk, reproductive immunology recurrent miscarriage infertility overlap, obstetrical history secondary infertility spontaneous abortion, live birth rate unexplained secondary infertility, immunological factors recurrent abortion infertility, bidirectional association infertility recurrent pregnancy loss
PMID 1418404 1418404 DOI 10.1111/j.1600-0897.1992.tb00739.x 10.1111/j.1600-0897.1992.tb00739.x
Cite this article
Coulam, C. B. (1992). Association between infertility and spontaneous abortion. *American journal of reproductive immunology (New York, N.Y. : 1989)*, *27*(3-4), 128-129. https://doi.org/10.1111/j.1600-0897.1992.tb00739.x
Coulam CB. Association between infertility and spontaneous abortion. Am J Reprod Immunol. 1992;27(3-4):128-129. doi:10.1111/j.1600-0897.1992.tb00739.x
Coulam, C. B. "Association between infertility and spontaneous abortion." *American journal of reproductive immunology (New York, N.Y. : 1989)*, vol. 27, no. 3-4, 1992, pp. 128-129.
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