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Infections and the Reproductive Microbiome Chronic Endometritis

Chronic endometritis and reproductive failure: Role of syndecan-1

Xu Y, Mei J, Diao L, Li Y, Ding L

Published September 2020 American journal of reproductive immunology (New York, N.Y. : 1989), 84(3), e13255
DOI 10.1111/aji.13255 PMID 32329146

Abstract

Chronic endometritis (CE) is an unusual inflammatory condition characterized by endometrial plasmacyte infiltration. It has a high prevalence in women with reproductive failure. Because of its characteristic localization patterns and molecular functions, syndecan-1 has been identified as a biomarker of plasmacyte, and syndecan-1 immunohistochemistry (IHC) becomes the most dependable diagnostic method for CE. In this review, we discuss the association between CE and reproductive failure, the clinicopathological characterization of CE, the function and expression of syndecan-1, the progress of syndecan-1 IHC in the diagnosis of CE, and the prediction of reproductive outcome.

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Infections and the Reproductive Microbiome › Chronic Endometritis › Diagnosis of Chronic Endometritis · Diagnostics › Endometrial Assessment › Endometrial Infection · Genetics and Immunology › Reproductive Immunology › Inflammation and Reproduction
Yanhong Xu, Jie Mei, Lianghui Diao, Yuye Li, Lijun Ding
Y Xu, J Mei, L Diao, Y Li, L Ding
PMID 32329146 32329146 DOI 10.1111/aji.13255 10.1111/aji.13255 Xu et al. 2020, Xu 2020

Keywords

chronic endometritis, plasmacyte, reproductive failure, syndecan-1

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