Epigenetic changes, geography and environmental factors do surpass the genetic factors in the development of breast cancer. This study investigates the association of reproductive factors with the breast cancer in this context.
Objective
To detect the association of reproductive risk factors with breast cancer in an urban set up at central India.
The study was conducted for a period of a year from October 2008 to August 2009 in Bhopal (MP). Demographic data and reproductive risk factor related information were collected using structured questionnaire. Data analysis was done by Epi-info and SPSS 16.
Results
History of using oral contraceptive pills (OR = 3.02, 95% CI: 1.28-7.11), history of not having breastfeeding (OR = 3.62, 95% CI: 1.29-10.16) and family history of breast cancer (OR = 3.98, 95%CI: 1.06-14.826) were associated significantly with the occurrence of breast cancer in multivariate analysis.
Conclusions
The findings of the present study suggests that positive family history of breast cancer and history of using OCP may be the epigenetic factors promoting the occurrence of breast cancer while breastfeeding reduces the possibility of acquiring breast cancer.
reproductive factors breast cancer risk case-control study India, oral contraceptive pill breast cancer risk association, breastfeeding protective effect breast cancer India, family history breast cancer reproductive risk factors, OCP use breast cancer odds ratio case-control, reproductive risk factors breast cancer urban central India, Lodha reproductive factors breast cancer Bhopal India, oral contraceptive breast cancer epigenetic environmental factors, breastfeeding duration breast cancer protection matched case-control, nulliparity contraceptive use breast cancer epidemiology India
PMID 21921328 21921328 DOI 10.4103/0019-509X.84928 10.4103/0019-509X.84928
Cite this article
Lodha, R., Joshi, A., Paul, D., Lodha KM, Nahar, N., Shrivastava, A., Bhagat VK, & Nandeshwar, S. (2011). Association between reproductive factors and breast cancer in an urban set up at central India: a case-control study. Indian journal of cancer, 48(3), 303-307. https://doi.org/10.4103/0019-509X.84928
Lodha R, Joshi A, Paul D, Lodha KM, Nahar N, Shrivastava A, et al. Association between reproductive factors and breast cancer in an urban set up at central India: a case-control study. Indian J Cancer. 2011;48(3):303-307. doi:10.4103/0019-509X.84928
Lodha, Rama, et al. "Association between reproductive factors and breast cancer in an urban set up at central India: a case-control study." Indian journal of cancer, vol. 48, no. 3, 2011, pp. 303-307.
Keywords
Contraceptives, Oral, Hormonal
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