Don't panic: IVF efficiency in the USA remains strong

Hill MJ, Kawwass JF, Eaton JL

Human reproduction open, 2026(3), hoag060, 2026
DOI 10.1093/hropen/hoag060 PMID 42542780 PMC PMC13428317

RRM Academy Synopsis

SART leaders argue IVF efficiency is stable once banking is excluded

Three SART leaders argue US births per IVF cycle have held near 32%, once cycles that froze embryos for later leave the count. Their 2026 letter answers a study of national CDC data. The letter also reports a gap in the records. SART data recorded banking in about 1 out of 10 cycles where it happened.

Study at a glance, letter to the editor: Letter argues US IVF counts should leave out embryo banking cycles
Study at a glance, letter to the editor: Letter argues US IVF counts should leave out embryo banking cycles. Source: Hill MJ et al., 2026, PMID 42542780.

Key Findings

  • The authors write as SART leaders and reject the label of IVF add-on for embryo banking, describing it as a family building option for patients who are appropriately counseled.
  • Gleicher et al. divided live births by every IVF cycle started. The letter leaves out cycles that froze embryos for later and reads the rest as stable at around 32%.
  • CDC and historic SART tables, the letter says, count a cycle with stored but untransferred embryos as negative once a 1-year window for transfer has passed.
  • In 2014 to 2017 SART data, cycles that froze embryos with no transfer within 1 year were reported as banking roughly 10% of the time. The rest counted as negative cycles.
  • In the letter's worked example, a 38-year-old completes three IVF cycles to get six embryos, transfers one embryo and has one live birth.

Interpretation

The paper is a three-author letter to the editor. The letter reports no new data and offers an opinion on how national IVF results should be counted. Its 32% figure is a reading of another team's table of CDC counts, and the letter does not show the arithmetic. The underreporting figure comes from a 2024 abstract by McCulloh and colleagues, on which Hill is a co-author. The abstract defined banking by what happened in each cycle, while the registry label followed the plan made beforehand. The worked example is an illustration, with no patient outcomes behind it. The letter discusses only US registries and declares no financial conflicts of interest.

RRM Context

Many restorative reproductive medicine (RRM) cohort studies report outcomes per couple. SART's own 2021 national report already prints a per-patient figure. Among women aged 38 to 40 using their own eggs, 42.6% of new patients had a live birth. The same report prints 26.0% live births per intended egg retrieval, counting every transfer within a year.

Abstract not indexed.

RRM Academy response · 14 October 2026

SART's leaders lift IVF's success rate by leaving out frozen-embryo cycles, and admit their records mislabeled most

Three IVF doctors (reproductive endocrinologists), writing "as leaders of the Society for Assisted Reproductive Technology (SART)," say US IVF results hold steady at about 32% if one kind of cycle is left out: the cycles where embryos were frozen for later and none was transferred (Hill et al. 2026). Each of those cycles was still a full round of stimulation drugs and an egg retrieval for a woman. The same letter says SART's records labeled those cycles correctly only about 1 time in 10. The letter declares "no financial conflicts of interest," while CMS Open Payments lists $21,672.39 to its first author from 2023 to 2025, $20,796.01 of it from Ferring (Open Payments profile).

  1. Leaving out frozen-embryo cycles raises the rate

    The SART leaders get to 32% by leaving some women's cycles out of the count. In an IVF cycle, a woman takes stimulation drugs, a doctor retrieves her eggs, and the lab makes embryos. The CDC counts a started cycle as "an ovarian stimulation cycle initiated with the intent to retrieve oocytes" (Gleicher et al. 2026). In a banking cycle, the embryos are frozen for later, and none is transferred in that cycle.

    Gleicher and colleagues divided each year's US live births by every IVF cycle started that year. On CDC data, that rate fell from 29.1% in 2012 to 22.2% in 2021. Over the same years, banking cycles rose from 18,585 to 167,689 (Gleicher et al. 2026).

    The SART leaders take the banking cycles out of the cycles they divide by. "When embryo banking cycles are excluded," they write, "ART cycle efficiency in the USA has been stable over the decade at around 32%" (Hill et al. 2026). The letter does not show the calculation.

    Each dropped cycle was still a full round of stimulation drugs and an egg retrieval for a woman. In 2021, 167,689 of the 413,776 cycles started were banking cycles. Taking them out of the count makes the rate higher. What those women went through stays the same.

  2. SART's records logged most frozen-embryo cycles as failures

    The letter says the national records got most banking cycles wrong. In 2014 to 2017 SART data, some cycles ended with embryos frozen and no transfer within a year. The registry recorded only about 1 in 10 of them as banking. In the letter's words, banking "was reported in roughly 10% of IVF cycles where embryo banking actually occurred." The rest went into the national figures as failed attempts (Hill et al. 2026).

    The letter explains the gap through two definitions. The registry's label rested on what the letter calls "the precycle intention," the plan stated before the cycle began. The study the letter cites, a 2024 abstract by McCulloh and colleagues on which Hill is a co-author, labeled banking by what actually happened: embryos frozen, with no transfer attempted within a year (Hill et al. 2026).

    The result is a national record that does not say what happened in most of these cycles. RRM Academy's ART Reporting Completeness (ARC) project measures this kind of gap: what each IVF registry publishes and what it leaves out. The SART leaders' letter states the gap itself: "In the CDC tables and the historic SART tables, embryo banking is grossly underreported compared to what actually happened." SART's 2021 national report also prints no figure for ovarian hyperstimulation syndrome (OHSS), ectopic pregnancy, procedure complications or maternal death (SART 2021 national report).

    Gleicher's team agreed in reply that historical CDC and SART reporting structures "incompletely account for delayed transfers and prolonged embryo storage." Their reply closes by noting that the three SART leaders "conclude their critique of our paper by acknowledging important deficiencies in the CDC and SART databases" (Gleicher et al. reply).

  3. Her example: three retrievals, one baby so far

    The letter's own example is one woman, three egg retrievals and one baby so far: "a 38-year-old patient wants three children and performs three IVF cycles to get six embryos. She then transfers the top embryo, which happens to be from Cycle 3, and has a live birth." The letter objects that the CDC tables count Cycles 1 and 2 as negative while their embryos sit in storage (Hill et al. 2026).

    For the woman, the count is three rounds of stimulation drugs, three egg retrievals and one baby. Her other embryos remain frozen, and later transfers may add births. Gleicher's team wrote that "Patients experience those cycles as real treatment burden, cost, delay, and risk" (Gleicher et al. reply).

    A per-patient count follows each woman from her first stimulation across all her cycles, and SART already prints one. In its 2021 national report, among women aged 38 to 40 using their own eggs, 42.6% of new patients had a live birth. The same report prints 26.0% live births per intended egg retrieval, counting all transfers within a year (SART 2021 national report). For women 38 to 40, the CDC's report for the same year lists an average of 4.3 intended retrievals per live-birth delivery, counting retrievals started in 2020 (CDC 2021 national report).

  4. Open Payments lists Ferring payments to Hill

    The letter states: "The authors have no financial conflicts of interest." CMS Open Payments lists 32 records for Micah Hill from 2023 through 2025, totaling $21,672.39. Ferring accounts for $20,796.01 of it (Open Payments profile).

    The records include $13,399.62 in Ferring Pharmaceuticals AS travel and lodging in Rome, Italy, dated September 23, 2025. They also include a $3,290 payment from Ferring Pharmaceuticals Inc. for speaking or faculty services on February 13, 2025, with Menopur listed as the product. Nine records name Menopur, Ferring's IVF stimulation drug.

    The letter's references were last accessed in February 2026, so all 32 records fall within the 36 months before it was written. RRM Academy found no Open Payments records for Jennifer Kawwass. Open Payments lists $127 in meals for Jennifer Eaton.

    Each banking cycle the letter defends is a stimulation cycle, and Menopur is a stimulation drug.

  5. Restorative care counts the couple

    Restorative reproductive medicine (RRM) starts with the question IVF skips: why conception has not happened, in both partners. Many RRM cohort studies report outcomes per couple, followed through care. Of the IVF figures, the per-patient count is the closest match, and SART publishes it.

    The letter argues over which cycles to leave out of the count. The woman in its example still went through three stimulations for one birth. For couples, the useful IVF number is the per-patient one, with the harms printed beside it.

What the paper establishes

The letter shows that three SART leaders read US IVF results as stable when cycles with frozen, untransferred embryos are left out of the count. The letter also says banking was "grossly underreported" in the CDC and historic SART tables, with most such cycles in 2014 to 2017 SART data counted as failures. The letter reports no new data. Its own example remains three stimulations and one baby so far, and its first author's Ferring payments sit beside a declaration of no financial conflicts.

Sources

  1. Hill et al. 2026 doi.org
  2. Open Payments profile openpaymentsdata.cms.gov
  3. Gleicher et al. 2026 pubmed.ncbi.nlm.nih.gov
  4. SART 2021 national report sartcorsonline.com
  5. Gleicher et al. reply doi.org
  6. CDC 2021 national report stacks.cdc.gov

By this author

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PMID 42542780 42542780 DOI 10.1093/hropen/hoag060 10.1093/hropen/hoag060 Hill et al. 2026, Hill 2026