Pregnancy Pregnancy Complications

Cytokines and immuno-endocrine factors in recurrent miscarriage

Lim KJ, Odukoya OA, Li TC, Cooke ID

Published November 1996 Human reproduction update, 2(6), 469-481
DOI 10.1093/humupd/2.6.469 PMID 9111182

Abstract

Recurrent miscarriage remains an enigma. The main aetiologies are endocrinological, immunological and unexplained. With the growth in molecular biology, it is now possible to look at the effect of these aetiologies in more detail, allowing greater understanding of the underlying pathogenesis.

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    Miscarriage affects approximately 15% of clinically confirmed pregnancies. Recurrent pregnancy loss (RPL), defined as two or more clinical losses, affects 2 to 5% of couples. Most causes are diagnosable and treatable. This guide covers what the standard workup misses, what RRM-trained clinicians evaluate, and what outcomes look like after cause-based treatment.

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Pregnancy › Pregnancy Complications › Intrauterine Infection · Infertility › Recurrent Pregnancy Loss › Immune and Thrombophilia Factors · Genetics and Immunology › Reproductive Immunology › Inflammation and Reproduction
Ian D Cooke
I Cooke
PMID 9111182 9111182 DOI 10.1093/humupd/2.6.469 10.1093/humupd/2.6.469 Lim et al. 1996, Lim 1996