Abstract
Objectives To investigate the efficacy of hCG in the management of recurrent early pregnancy loss.
Design A prospective, randomized, controlled trial.
Setting Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.
Subjects Eighty-one women attending the miscarriage clinic with idiopathic recurrent pregnancy loss were randomized to receive hCG supplementation or placebo in early pregnancy.
Main Outcome Measure The success rate or live birth rate.
Results In women with regular menstrual cycles it was found that hCG had no beneficial effect, the pregnancy success rate being 86% in both groups. However, women with oligomenorrhea had a pregnancy success rate of 40% in the placebo group but a statistically significant improvement to 86% if hCG was given.
Conclusions Human chorionic gonadotropin can be recommended for idiopathic recurrent pregnancy loss in women with oligomenorrhea.
hCG supplementation recurrent pregnancy loss randomized controlled trial, human chorionic gonadotropin recurrent miscarriage treatment, oligomenorrhea recurrent pregnancy loss hCG efficacy, Quenby Farquharson hCG recurrent miscarriage, idiopathic recurrent pregnancy loss hormonal support, hCG early pregnancy support live birth rate, progesterone support alternatives recurrent miscarriage, oligomenorrhea irregular cycles miscarriage treatment, placebo controlled trial hCG pregnancy loss, luteal phase support recurrent early pregnancy loss
PMID 7646609 7646609 DOI 10.1016/s0015-0282(16)56992-1 10.1016/s0015-0282(16)56992-1
Keywords
Abortion, Habitual/complications/drug Therapy, Adult, Chorionic Gonadotropin/therapeutic Use, Female, Humans, Menstrual Cycle, Oligomenorrhea/complications, Pregnancy, Pregnancy Outcome, Prospective Studies, Reference Values, Chorionic Gonadotropin