Treatment of habitual abortion with human chorionic gonadotropin: results of open and placebo-controlled studies

Robert F. Harrison

doi:10.1016/0028-2243(85)90015-2

Therapeutics · Hormonal Agents

Treatment of habitual abortion with human chorionic gonadotropin: results of open and placebo-controlled studies

Harrison RF

Published September 1985 European Journal of Obstetrics, Gynecology, and Reproductive Biology, 20(3), 159-168

DOI 10.1016/0028-2243(85)90015-2 PMID 3902523

Abstract

Human chorionic gonadotropin was administered intramuscularly in an open study of 32 women whose last three pregnancies had ended in spontaneous abortion. An initial dosage of 10 000 iu on earliest diagnosis of pregnancy was followed up by 5000 IU twice weekly up to wk 12, then once weekly up to wk 16. Only 2 of the 32 patients aborted (6.2%). Using the same regime a further 20 habitual aborters were randomly allocated double-blind to either hCG or placebo. All 10 women on active therapy continued (100%) compared with only 3 on placebo (30%) (P less than 0.01). These results suggest that hCG should be considered as treatment in women with habitual abortion where other specific causes have been ruled out and a potentially treatable hormonal imbalance surmised.

Topics

Therapeutics › Hormonal Agents › Gonadotropins · Pregnancy › Pregnancy Complications › Premature Rupture of Membranes · Reproductive Endocrinology › Luteal Phase › Corpus Luteum Function

Robert F. Harrison

Bob Harrison, Rob Harrison, Bobby Harrison, R Harrison

PMID 3902523 3902523 DOI 10.1016/0028-2243(85)90015-2 10.1016/0028-2243(85)90015-2 Harrison et al. 1985, Harrison 1985

Keywords

Abortion, Habitual/drug Therapy, Adult, Chorionic Gonadotropin/therapeutic Use, Clinical Trials As Topic, Female, Humans, Infant Mortality, Parity, Pregnancy, Progesterone/blood, Chorionic Gonadotropin, Progesterone

Treatment of habitual abortion with human chorionic gonadotropin: results of open and placebo-controlled studies

Abstract

Topics

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Keywords