Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

R. F. Harrison; E. Youssefnejadian; Hilary Brodovcky; M. Johnson; John Dewhurst

doi:10.1111/j.1471-0528.1978.tb15855.x

Reproductive Endocrinology · Ovarian Hormones

Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Harrison RF, Youssefnejadian E, Brodovcky H, Johnson M, Dewhurst J

Published December 1978 British Journal of Obstetrics and Gynaecology, 85(12), 927-932

DOI 10.1111/j.1471-0528.1978.tb15855.x PMID 737159

Abstract

Plasma progesterone, 17-hydroxyprogesterone, 20alpha hydroxypregn-4-en-3-one levels were determined twice weekly up to 16 weeks gestation, where possible, in a twin pregnancy, in two patients who aborted spontaneously and in three patients who were treated with 'progesterone supplements' because of abnormal vaginal cytology. There was no correlation between vaginal smears and the plasms hormone levels and there was no evidence to suggest that progesterone supplements influenced clinical outcome. Compared with normal mean values the only difference was a significantly rise in progesterone and 20alpha hydroxypregn-4-en-3-one levels in the twin pregnancy after the 12th week and a precipitate fall in all hormone levels just prior to abortion. Plasma hormone levels could not be used to predict outcome.

Topics

Reproductive Endocrinology › Ovarian Hormones › Progesterone · Pregnancy › Early Pregnancy › Miscarriage · Diagnostics › Hormone Testing › Serum Panels

Hilary Brodovcky, John Dewhurst

H Brodovcky, Jack Dewhurst, J Dewhurst

PMID 737159 737159 DOI 10.1111/j.1471-0528.1978.tb15855.x 10.1111/j.1471-0528.1978.tb15855.x Harrison et al. 1978, Harrison 1978

Keywords

20-alpha-Dihydroprogesterone/blood/metabolism, Abortion, Spontaneous/blood, Female, Humans, Hydroxyprogesterones/blood/metabolism, Pregnancy, Pregnancy Complications/blood/physiopathology, Pregnancy Trimester, First, Pregnancy, Multiple, Progesterone/analogs & Derivatives/blood/metabolism, Progesterone Congeners/therapeutic Use, Hydroxyprogesterones, Progesterone Congeners, 20-alpha-Dihydroprogesterone, Progesterone

Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Abstract

Topics

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