In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study

Kirsten Wisborg; Hans Jacob Ingerslev; Tine Brink Henriksen

doi:10.1016/j.fertnstert.2010.01.014

Assisted Reproduction · Safety and Risks

In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study

Wisborg K, Ingerslev HJ, Henriksen TB

Published November 2010 Fertility and sterility, 94(6), 2102-6

DOI 10.1016/j.fertnstert.2010.01.014 PMID 20188361

Abstract

Objective

To compare the risk of preterm delivery, low birth weight, and admission of the newborn to a neonatal intensive care unit (NICU) in women pregnant after fertility treatment and subfertile women with the risk in fertile women.

Design

Prospective follow-up study.

Setting

Aarhus University Hospital, Skejby, Denmark, 1989-2006.

Patients

A total of 20,080 liveborn singletons.

Interventions

None.

Main Outcome Measures

Preterm delivery, low birth weight, and admission of the newborn to a NICU.

Results

After adjustment we found a statistically significantly increased risk of preterm delivery and very preterm delivery in women who conceived after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) compared with fertile women. Compared with fertile women, the risk of preterm delivery and very preterm delivery was not statistically significantly different in women pregnant after non-IVF assisted reproductive treatment (non-IVF ART) or subfertile women. We found no association between IVF/ICSI and the risk of low birth weight at term or admittance to the NICU.

Conclusions

The increased risk of preterm delivery after IVF/ICSI may be due to the fertility treatment or unknown characteristics in the couples who undergo IVF/ICSI.

Topics

Assisted Reproduction › Safety and Risks › Neonatal and Birth Outcomes · Pregnancy › Preterm Birth › Prediction · Birth and Delivery › Birth Outcomes › Maternal Morbidity

Kirsten Wisborg, Hans Jacob Ingerslev, Tine Brink Henriksen

K Wisborg, H Ingerslev, T Henriksen

PMID 20188361 20188361 DOI 10.1016/j.fertnstert.2010.01.014 10.1016/j.fertnstert.2010.01.014 Wisborg et al. 2010, Wisborg 2010

In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study

Abstract

Topics

By this author

Related research