Letrozole increases ovulation in women with infertility being treated with Natural Procreative Technology (NPT)

At least 15% of couples are affected by infertility each year. • Natural Procreative Technology (NPT): A noninvasive fertility treatment to optimize normal reproductive function, which includes: • Medical intervention to normalize a fertility cycle • Menstrual cycle tracking of fertility biomarkers such as changes in vaginal discharge and bleeding using Creighton Model FertilityCare System (CrMS) • Objective: To determine the association of different medications with changes in menstrual cycle parameters, specifically ovulation, in couples with subfertility. Inclusion: Women with infertility ages 18 years or older, enrolled in iNEST study • Exclusion: CrMS charts with missing/incomplete data • Analysis: Descriptive statistics of medication frequency; Generalized linear models DISCUSSION • NPT is a novel form of infertility treatment. • This study is among one of the first of its kind, which paves the way for future studies specifically designed to evaluate medication effect during the menstrual cycle. • Limitations include data collection and adherence assessment due to self-reporting nature of CrMS.