South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 48(34), 1456-1458, 1974
Abstract
Summary
The use of clomiphene in gradually increasing doses, in cases of infertility due to anovulation, oligo-ovulation and inadequate luteal phase, led to a high pregnancy rate, particularly in the initial stages of treatment. Although clomiphene is a relatively safe and inexpensive drug, there is a possibility that high doses in repeated cycles may adversely affect fertility by its anti-oestrogenic effect. It is therefore suggested that therapy be commenced with a lower dosage than that generally recommended.
Topics
low dose clomiphene infertility anovulation treatment, clomiphene citrate inadequate luteal phase therapy, clomiphene dose escalation ovulation induction, anti-estrogenic effect clomiphene high dose fertility, Barrett Hakim clomiphene low dosage infertility, oligo-ovulation clomiphene treatment pregnancy rate, clomiphene starting dose recommendation infertility, anovulatory infertility oral ovulation induction agents, clomiphene repeated cycles adverse fertility effects, defective ovulation clomiphene graduated dosing protocol
Barrett et al. 1974, Barrett 1974
Cite this article
Barrett, C. T., & Hakim, C. A. (1974). Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 48(34), 1456-1458.
Barrett CT, Hakim CA. Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation. S Afr Med J. 1974;48(34):1456-1458.
Barrett, Carolyn T., and C. A. Hakim. "Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation." South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, vol. 48, no. 34, 1974, pp. 1456-1458.
Keywords
Abortion, Spontaneous/epidemiology, Adult, Amenorrhea/drug Therapy, Body Temperature, Clomiphene/administration & Dosage/pharmacology/therapeutic Use, Female, Humans, Infertility, Female/drug Therapy/physiopathology, Ovulation/drug Effects, Pregnancy, Pregnancy, Ectopic/epidemiology, Pregnancy, Multiple, Twins, Clomiphene
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