South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 48(34), 1456-1458, 1974
Abstract
Summary
The use of clomiphene in gradually increasing doses, in cases of infertility due to anovulation, oligo-ovulation and inadequate luteal phase, led to a high pregnancy rate, particularly in the initial stages of treatment. Although clomiphene is a relatively safe and inexpensive drug, there is a possibility that high doses in repeated cycles may adversely affect fertility by its anti-oestrogenic effect. It is therefore suggested that therapy be commenced with a lower dosage than that generally recommended.
Topics
Cite this article
Barrett, C. T., & Hakim, C. A. (1974). Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation. *South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde*, *48*(34), 1456-1458.
Barrett CT, Hakim CA. Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation. S Afr Med J. 1974;48(34):1456-1458.
Barrett, Carolyn T., and C. A. Hakim. "Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation." *South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde*, vol. 48, no. 34, 1974, pp. 1456-1458.
Keywords
Abortion, Spontaneous/epidemiology, Adult, Amenorrhea/drug Therapy, Body Temperature, Clomiphene/administration & Dosage/pharmacology/therapeutic Use, Female, Humans, Infertility, Female/drug Therapy/physiopathology, Ovulation/drug Effects, Pregnancy, Pregnancy, Ectopic/epidemiology, Pregnancy, Multiple, Twins, Clomiphene