Mefenamic acid in the treatment of premenstrual syndrome

Mira M; McNeil D; Fraser IS; Vizzard J; Abraham S

doi:10.1097/00006250-198609000-00022

Therapeutics · Anti-Infective and Anti-Inflammatory Agents

Mefenamic acid in the treatment of premenstrual syndrome

Mira M, McNeil D, Fraser IS, Vizzard J, Abraham S

Published September 1986 Obstetrics and Gynecology, 68(3), 395-398

DOI 10.1097/00006250-198609000-00022 PMID 3526218

Abstract

The use of mefenamic acid in the treatment of premenstrual syndrome (PMS) was investigated in 15 women over six menstrual cycles. A randomized, double-blind, cross-over, placebo-controlled design was used to overcome the methodologic criticisms of other medication trials in this condition. Mefenamic acid significantly improved many of the physical, mood, and performance symptoms associated with PMS. The physical symptoms that showed marked improvement were fatigue, headache, and general aches and pains (P less than .001). Most mood symptoms were improved, the most significant being freedom from mood swings (P less than .005).

Topics

Therapeutics › Anti-Infective and Anti-Inflammatory Agents › Nonsteroidal Anti-Inflammatory Drugs · Menstrual Cycle › Premenstrual Disorders › Premenstrual Syndrome Treatment

Ian S Fraser

I Fraser

PMID 3526218 3526218 DOI 10.1097/00006250-198609000-00022 10.1097/00006250-198609000-00022 Mira et al. 1986, Mira 1986

Keywords

Adult, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Mefenamic Acid/adverse Effects/therapeutic Use, Menstrual Cycle, Premenstrual Syndrome/drug Therapy, Prospective Studies, Mefenamic Acid

Mefenamic acid in the treatment of premenstrual syndrome

Abstract

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