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Progesterone - Friend or foe?

Sundström-Poromaa I et al., 2020 Open Access Frontiers in Neuroendocrinology

Estradiol is the "prototypic" sex hormone of women. Yet, women have another sex hormone, which is often disregarded: Progesterone. The goal of this article is to provide a comprehensive review on prog...

Reproductive Endocrinology > Progesterone > Neuroendocrine EffectsMenstrual Cycle > Premenstrual Disorders > Progesterone and MoodPostpartum > Depression > Allopregnanolone Treatment

A Risk Assessment Tool for Predicting Fragility Fractures and Mortality in the Elderly

Thach Tran et al., 2020 J Bone Miner Res

Existing fracture risk assessment tools are not designed to predict fracture-associated consequences, possibly contributing to the current undermanagement of fragility fractures worldwide. We aimed to...

Bone Health > Fractures > Risk Prediction ModelsPerimenopause/Menopause > Osteoporosis > Fracture Risk AssessmentResearch Methodology > Statistical Models > Multistate Prediction

Are glyphosate and glyphosate-based herbicides endocrine disruptors that alter female fertility?

Ingaramo P et al., 2020 Molecular and Cellular Endocrinology

Numerous evidences have alerted on the toxic effects of the exposure to glyphosate on living organisms. Glyphosate is the herbicide most used in crops such as maize and soybean worldwide, which implie...

Infertility > Environmental Factors > Endocrine DisruptorsReproductive Endocrinology > Environmental Toxicology > Herbicide EffectsGeneral OB/GYN > Environmental Health > Reproductive Toxicants

Deficits in bone strength, density and microarchitecture in women living with HIV: A cross-sectional HR-pQCT study

Heather M Macdonald et al., 2020 Bone

Purpose: With the advent of combined antiretroviral therapy (cART), life expectancy has increased among persons living with HIV, but so too has risk for comorbidities including osteoporosis and fragil...

Bone Health > HIV-Related Bone Loss > Antiretroviral Therapy EffectsMenstrual Cycle > Reproductive Status > Bone Mineral DensityBone Health > Bone Microarchitecture > HR-pQCT Assessment

Nonsurgical Management of Oligozoospermia

Choy JT et al., 2020 The Journal of Clinical Endocrinology and Metabolism

Male infertility secondary to oligozoospermia is surprisingly common. Although a majority of cases are idiopathic, oligozoospermia can be caused by endocrine dysfunction, anatomic abnormalities, medic...

AndrologyInfertility

Effects of progesterone therapy on serum sclerostin levels in healthy menopausal women: a 3-month randomized, placebo-controlled clinical trial

Yang YB et al., 2020 Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Sclerostin, a natural hormone made in bone, suppresses bone formation. Sclerostin is also decreased by estrogen. Progesterone, estrogen's menstrual partner, stimulates bone formation. It is unclear wh...

Perimenopause/Menopause > Hormone Therapy > ProgesteroneBone Health > Bone Biomarkers > SclerostinResearch Methodology > Randomized Controlled Trial > Post Hoc Analysis

The Prevalence of Autoimmune Disorders in Women: A Narrative Review

Angum F et al., 2020 Open Access Cureus

Autoimmune disorders are characterized as a condition in which the host's immune system mistakenly attacks itself. These disorders cause the immune system to cause a systemic reaction by attacking mul...

General OB/GYNReproductive Endocrinology

Endometrial Decidualization: The Primary Driver of Pregnancy Health

Ng SW et al., 2020 Open Access International Journal of Molecular Sciences

Interventions to prevent pregnancy complications have been largely unsuccessful. We suggest this is because the foundation for a healthy pregnancy is laid prior to the establishment of the pregnancy a...

Reproductive EndocrinologyPregnancy

Fertility Treatment 2018: Trends and Figures

Human Fertilisation and Embryology Authority, 2020

# Fertility treatment 2018: trends and figures **UK statistics for IVF and DI treatment, storage, and donation** Published: 30 June 2020 Fertility trends is our annual statistical release. The key fin...

Infertility > Assisted Reproductive Technology > IVF OutcomesInfertility > Epidemiology > National StatisticsResearch Methodology > Epidemiological Data > Population-Level Trends

Persistent organic pollutant exposure and celiac disease: A pilot study

Gaylord A et al., 2020 Environmental Research

Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollu...

General OB/GYN > Environmental Health > Endocrine DisruptorsDiagnostics > Autoimmune Disease > Environmental Risk FactorsResearch Methodology > Pilot Study > Cross-Sectional Design

MON-LB9 Cyclic Progesterone Therapy in Androgenic Polycystic Ovary Syndrome (PCOS) - Person-Related 6-Month Experience Changes

Shirin S et al., 2020 Open Access Journal of the Endocrine Society

Endometrial cancer1 and oligomenorrhea2 are common risks for women living with androgenic PCOS (WLWP); cyclic progesterone therapy could prevent both. Cyclic oral micronized progesterone therapy (Cycl...

PCOS > Treatment > Cyclic Progesterone TherapyReproductive Endocrinology > Progesterone > Luteal Phase ReplacementPCOS > Symptoms > Oligomenorrhea Management

MON-LB010 Cyclic Progesterone Therapy for Androgenic Polycystic Ovary Syndrome (PCOS) - A Systematic Review of the Literature

Shirin S et al., 2020 Open Access Journal of the Endocrine Society

Women living with androgenic PCOS (WLWP) experience unpredictable oligomenorrhea1 and are at increased risk for endometrial cancer2. Oral micronized progesterone (OMP) given cyclically (14 days/cycle ...

PCOS > Treatment > Cyclic Progesterone TherapyResearch Methodology > Systematic Review > Literature SearchPCOS > Pathophysiology > Neuroendocrine Mechanisms

Prolonged Amenorrhea and Low Hip Bone Mineral Density in Women Living With HIV-A Controlled Cross-sectional Study

EM King et al., 2020 J Acquir Immune Defic Syndr

Background: Women living with HIV (WLWH) have higher rates of prolonged secondary amenorrhea (no flow for ≥1 year) than HIV-negative women. Both having amenorrhea and being HIV positive are associated...

Menstrual Cycle > Amenorrhea > HIV-AssociatedBone Health > Bone Mineral Density > Amenorrhea EffectsGeneral OB/GYN > Women Living with HIV > Reproductive Health

Use of menstruation and fertility app trackers: a scoping review of the evidence

Earle S et al., 2020 BMJ Sexual & Reproductive Health

Introduction: There has been a phenomenal worldwide increase in the development and use of mobile health applications (mHealth apps) that monitor menstruation and fertility. Critics argue that many of...

Body Literacy > Digital Tools > Fertility App EvaluationFertility Awareness > Technology > Mobile Health ApplicationsResearch Methodology > Scoping Review > mHealth Evidence

Naltrexone

No Authors Listed, 2020 LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]

Naltrexone is a synthetic opioid antagonist used in prevention of relapse of opiate addiction and alcoholism. Naltrexone has been associated with low rates of serum enzyme elevations during therapy an...

General OB/GYN > Pharmacology > Opioid AntagonistsDiagnostics > Drug Safety > Hepatotoxicity

Fertility awareness-based methods of family planning

Simmons RG et al., 2020 Best Practice & Research. Clinical Obstetrics & Gynaecology

Fertility awareness-based methods (FABMs) of family planning involve monitoring various signs and symptoms of fertility during the menstrual cycle to identify the "fertile window," or the days of the ...

Fertility Awareness > Methods Overview > Signs and SymptomsFertility Awareness > Effectiveness > Pregnancy PreventionBody Literacy > Menstrual Cycle Monitoring > Fertility Signs

Mortality from infancy to adolescence in singleton children conceived from assisted reproductive techniques versus naturally conceived singletons in Sweden

Rodriguez-Wallberg KA et al., 2020 Fertility and Sterility

Objective: To assess infant (<1 year) and childhood (1-18 years) mortality in singletons conceived through assisted reproductive techniques (ART) versus naturally conceived singletons. Design: Nationw...

Infertility > ART Outcomes > Infant MortalityInfertility > IVF > Cryopreserved Embryo Transfer OutcomesResearch Methodology > Epidemiology > Prospective Cohort Studies

Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis

Asthana S et al., 2020 Eur J Obstet Gynecol Reprod Biol

Background: Role of Oral Contraceptive (OC) as a risk factor for cervical cancer remained controversial and unclear. Objective: To evaluate risk of cervical cancer in OC users and non-users through a...

Contraception/Comparison > Oral Contraceptives > Cancer RiskContraception/Comparison > Side Effects > Cervical CancerResearch Methodology > Systematic Review > Meta-Analysis

Combining Frailty and Trabecular Bone Score Did Not Improve Predictive Accuracy in Risk of Major Osteoporotic Fractures

Guowei Li et al., 2020 J Bone Miner Res

It is recognized that the trabecular bone score (TBS) provides skeletal information, and frailty measurement is significantly associated with increased risks of adverse health outcomes. Given the subo...

Bone Health > Fracture Risk Assessment > Predictive ModelsPerimenopause/Menopause > Osteoporosis > Fracture Risk FactorsResearch Methodology > Statistical Methods > Structural Equation Modeling

Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis

Zhang Y et al., 2020 Human Reproduction Update

Background: Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging tasks in reproductive medicine. OBJECTIVE AND Ra...

Infertility > IVF > Poor Ovarian Response TreatmentInfertility > Ovarian Stimulation > Adjuvant TherapiesResearch Methodology > Systematic Review > Network Meta-Analysis

Testing a theoretical model of imminent fracture risk in elderly women: an observational cohort analysis of the Canadian Multicentre Osteoporosis Study

A Papaioannou et al., 2020 Osteoporos Int

We examined the underlying relationship between fracture risk factors and their imminent risk. Results suggested that having past year fracture, worse past year general health, worse past year physica...

Bone Health > Fracture Risk Assessment > Imminent Risk PredictionPerimenopause/Menopause > Osteoporosis > Risk Factor ModelingResearch Methodology > Statistical Methods > Structural Equation Modeling

Levonorgestrel-releasing intrauterine system and breast cancer risk: A systematic review and meta-analysis

Conz L et al., 2020 Acta Obstetricia Et Gynecologica Scandinavica

Introduction: Epidemiological studies have shown that some hormonal contraceptive methods are associated with increased breast cancer risk, especially if used over long periods. Our objective was to c...

Contraception/Comparison > Intrauterine Devices > Breast Cancer RiskContraception/Comparison > Hormonal Contraception > Long-Term Side EffectsResearch Methodology > Systematic Review > Meta-Analysis

Knowledge about the impact of age on fertility: a brief review

Delbaere I et al., 2020 Open Access Upsala Journal of Medical Sciences

Delayed childbearing is currently a major challenge in reproductive medicine as increased age has an important impact on successful conception, both in natural and in assisted reproduction. There is a...

Body LiteracyInfertility

The effect of the copper intrauterine device (Cu-IUD) and the injectable depo-medroxyprogesterone acetate (DMPA) use on women’s sexual satisfaction and depression

SoleimanvandiAzar N et al., 2019 Open Access Nursing Practice Today

Background: Health service utilization (HSU) is a significant health and political issue. Awareness of factors that affect HSU and the status of health service utilization can help health professional...

Contraception/Comparison > Intrauterine Devices > Side EffectsContraception/Comparison > Injectable Contraception > Mental Health EffectsGeneral OB/GYN > Sexual Health > Contraception Impact

The Reproductive Microbiome: An Emerging Driver of Sexual Selection, Sexual Conflict, Mating Systems, and Reproductive Isolation

Rowe M et al., 2020 Open Access Trends in Ecology & Evolution

All multicellular organisms host microbial communities in and on their bodies, and these microbiomes can have major influences on host biology. Most research has focussed on the oral, skin, and gut mi...

Fertility Awareness > Reproductive Biology > Reproductive MicrobiomeReproductive Endocrinology > Microbiome > Sexual SelectionResearch Methodology > Review Articles > Evolutionary Biology

Adiposity and Endometriosis Severity and Typology

Byun J et al., 2020 Journal of Minimally Invasive Gynecology

STUDY Objective: Prior research has collectively shown that endometriosis is inversely related to women's adiposity. The aim of this study was to assess whether this inverse relationship holds true by...

Endometriosis

Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women

Di Nisio A et al., 2020 Chemosphere

Female fecundity is finely regulated by hormonal signaling, representing a potential target for endocrine-disrupting chemicals. Among the chemicals of most concern are the perfluoroalkyl substances (P...

Reproductive Endocrinology > Endocrine Disruptors > PFAS EffectsMenstrual Cycle > Irregular Menstruation > Environmental Chemical ExposureReproductive Endocrinology > Progesterone > Endometrial Function Disruption

Endometriosis. Reply

Becker CM et al., 2020 The New England journal of medicine
Endometriosis > Pathophysiology > Disease MechanismsEndometriosis > Diagnosis > Clinical Review