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Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa

Zou QX et al., 2017 Human reproduction (Oxford, England)

STUDY QUESTION: Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions? SUMMARY ANS...

Andrology > Sperm Function > Ion Channels and Calcium SignalingAndrology > Environmental Factors > Endocrine Disrupting ChemicalsReproductive Endocrinology > Progesterone > Non-Genomic Actions in Sperm

Densitometer-Specific Differences in the Correlation Between Body Mass Index and Lumbar Spine Trabecular Bone Score

Gillian Mazzetti et al., 2017 J Clin Densitom

Trabecular bone score (TBS) is a gray-level texture measure derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images that predicts fractures independent of bone mineral density (BMD). I...

Bone Health > Diagnostics > Trabecular Bone ScoreBone Health > Measurement > DXA DensitometryResearch Methodology > Measurement Validation > Device Comparison

Effectiveness of a Natural Family Planning Service Program

Fehring RJ et al., 2016 MCN. The American Journal of Maternal Child Nursing

Purpose: The aims of this study were to determine and compare extended use-effectiveness of an online nurse-managed fertility education service program among women (and subgroups of women) seeking to ...

Fertility Awareness > Methods > Electronic Fertility MonitoringFertility Awareness > Effectiveness > Typical and Perfect UseRRM Methods > Fertility Education > Online Programs

Premenopausal Osteoporosis

Prior JC, 2017 Endocrinology and metabolism clinics of North America

Most premenopausal women with low trauma fracture(s) or low bone mineral density have a secondary cause of osteoporosis or bone loss. Where possible, treatment of the underlying cause should be the fo...

Bone HealthPerimenopause/Menopause

Couple Beads: An integrated method of natural family planning

Mulcaire-Jones G et al., 2016 The Linacre Quarterly

Various fertility indicators are used by natural family planning methods to identify the fertile and infertile phases of a woman's menstrual cycle: mucus observations, cycle-day probabilities, basal b...

Fertility AwarenessRRM Methods

Prevalence and Symptomatic Burden of Diagnosed Endometriosis in the United States: National Estimates from a Cross-Sectional Survey of 59,411 Women

Fuldeore MJ et al., 2017 Gynecologic and obstetric investigation

Background/aims: To estimate the prevalence of diagnosed endometriosis (DE) in women in the United States and assess the associated symptomatic burden. Methods: An online, cross-sectional survey of w...

Endometriosis > Epidemiology > PrevalenceEndometriosis > Symptoms > Pelvic Pain and DyspareuniaResearch Methodology > Observational Studies > Cross-Sectional Survey

Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)

Fruzzetti F et al., 2016 Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology

Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. The purpose of t...

PCOS > Treatment > Insulin SensitizersPCOS > Treatment > Myo-InositolPCOS > Metabolic Features > Insulin Resistance

Association of Hormonal Contraception With Depression

Skovlund CW et al., 2016 JAMA Psychiatry

Importance: Millions of women worldwide use hormonal contraception. Despite the clinical evidence of an influence of hormonal contraception on some women's mood, associations between the use of hormon...

Contraception/Comparison > Side Effects > Depression and MoodContraception/Comparison > Hormonal Methods > Combined and Progestin-OnlyResearch Methodology > Observational Studies > Prospective Cohort

Fertility and Childbearing Among American Female Physicians

Stentz NC et al., 2016 Journal of Women's Health (2002)

Background: Female physicians may experience unique challenges regarding fertility and family planning. We sought to determine childbearing patterns and decision-making among American female physician...

Infertility > Risk Factors > Delayed ChildbearingInfertility > Epidemiology > Prevalence in Specific PopulationsGeneral OB/GYN > Women's Health > Career and Fertility

An update on the prevention of ovarian hyperstimulation syndrome

El Tokhy O et al., 2016 Open Access Women's Health

Ovarian hyperstimulation syndrome is a potentially life-threatening, but preventable iatrogenic complication of in vitro fertilisation treatment. In recent years, new strategies have been developed to...

Infertility > ART > Ovarian Hyperstimulation Syndrome PreventionInfertility > IVF Complications > OHSS Risk ReductionReproductive Endocrinology > Ovarian Stimulation > Safety Protocols

Progestin-only contraceptives: effects on weight

Lopez LM et al., 2016 The Cochrane Database of Systematic Reviews

Background: Progestin-only contraceptives (POCs) are appropriate for many women who cannot or should not take estrogen. POCs include injectables, intrauterine contraception, implants, and oral contrac...

Contraception/Comparison

Improving the safety of the embryo and the patient during fertilization procedures

Wdowiak A et al., 2016 Open Access Videosurgery and Other Miniinvasive Techniques

In vitro fertilization (IVF) is a method of treatment for infertility in selected indications. Recent years have brought dynamic development of technologies related to IVF. This article presents probl...

Contraception/Comparison > Assisted Reproduction > IVF SafetyInfertility > Assisted Reproductive Technology > IVF ProceduresEthics/Philosophy > Patient Safety > Embryo Protection

Diabetes and Sexuality

Kizilay F et al., 2017 Sex Med Rev

Introduction: Deterioration in sexual functioning is one of the major and serious complications of diabetes. This common metabolic disorder not only affects sexuality through microvascular and nerve d...

General OB/GYN > Sexual Health > Diabetes-Related Sexual DysfunctionAndrology > Sexual Dysfunction > Erectile DysfunctionReproductive Endocrinology > Metabolic Disorders > Diabetes and Hormones

Premenstrual Syndrome and Premenstrual Dysphoric Disorder

Hofmeister S et al., 2016 American Family Physician

Premenstrual disorders affect up to 12% of women. The subspecialties of psychiatry and gynecology have developed overlapping but distinct diagnoses that qualify as a premenstrual disorder; these inclu...

Menstrual Cycle > Premenstrual Disorders > PMS Diagnosis and TreatmentMenstrual Cycle > Premenstrual Disorders > PMDD ManagementMenstrual Cycle > Luteal Phase > Luteal Phase Symptoms

Sexual and physical abuse and gynecologic disorders

Schliep KC et al., 2016 Human reproduction (Oxford, England)

Study Question: Is sexual and/or physical abuse history associated with incident endometriosis diagnosis or other gynecologic disorders among premenopausal women undergoing diagnostic and/or therapeut...

General OB/GYNEndometriosis

The impact of depot medroxyprogesterone acetate on fracture risk: a case-control study from the UK

Kyvernitakis I et al., 2017 Osteoporos Int

There has been concerning about women receiving depot medroxyprogesterone acetate (DMPA) contraception because of the prolonged hypoestrogenemic state regarding the potential negative effects on bone ...

Bone Health > Contraceptive Effects > DMPA and Fracture RiskContraception/Comparison > Hormonal Contraception > Injectable Contraceptives Side EffectsReproductive Endocrinology > Bone Metabolism > Hypoestrogenism and Bone Loss

Diagnosis and Treatment of Polycystic Ovary Syndrome

Williams T et al., 2016 American Family Physician

Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients. Although the pathophysiology of the syndr...

PCOS > Diagnosis > Rotterdam CriteriaPCOS > Treatment > Metabolic ManagementPCOS > Treatment > Ovulation Induction

Emerging Manifestations of Cesarean Scar Defect in Reproductive-aged Women

Tulandi T et al., 2016 Journal of Minimally Invasive Gynecology

The objective of this study was to evaluate the prevalence of cesarean scar defects and its clinical manifestations in reproductive-aged women. We performed a systematic review following the Preferred...

Surgery > Uterine Surgery > Cesarean Scar Defect RepairGeneral OB/GYN > Cesarean Complications > Scar Defect ManifestationsInfertility > Uterine Factors > Cesarean Scar Defect and Fertility

The Performance of Fertility Awareness-based Method Apps Marketed to Avoid Pregnancy

Duane M et al., 2016 Journal of the American Board of Family Medicine : JABFM

Introduction: In recent years there has been an explosion in the development of medical apps, with more than 40,000 apps now available. Nearly 100 apps allow women to track their fertility and menstru...

Fertility Awareness > Digital Tools > Fertility App EvaluationFertility Awareness > Methods > Evidence-Based FABMsResearch Methodology > Evaluation Tools > App Assessment Instruments

Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study

Schliep KC et al., 2016 The American journal of clinical nutrition

Background: Clinicians often recommend limiting caffeine intake while attempting to conceive; however, few studies have evaluated the associations between caffeine exposure and menstrual cycle functio...

Menstrual CycleReproductive Endocrinology

Deep Retraction Pockets, Endometriosis, and Quality of Life

Yeung PP Jr et al., 2016 Open Access Frontiers in Public Health

Objective: The purpose of this study was to examine if deep retraction pockets (DRPs) in the posterior cul-de-sac and uterosacral ligaments could be a manifestation of endometriosis and if excision of...

EndometriosisSurgery

A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas

Pasta V et al., 2016 European Review for Medical and Pharmacological Sciences

Objective: Breast fibroadenoma is a common finding in young women and actually accounts for the majority of benign breast lumps. Fibroadenoma does not require any treatment unless clinical symptoms (m...

General OB/GYN > Breast Health > Fibroadenoma TreatmentResearch Methodology > Clinical Trials > Randomized Controlled TrialReproductive Endocrinology > Nutritional Supplements > Myo-inositol Therapy

Adolescents’ use of combined hormonal contraceptives for menstrual cycle–related problem treatment and contraception: evidence of potential lifelong negative reproductive and bone effects

Prior JC, 2016 Women's Reproductive Health

Non-sexually active adolescents are currently treated with combined hormonal contraception (CHC) for common experiences (e.g., cramps, acne) and serious problems (e.g., hypothalamic amenorrhea, heavy ...

Menstrual Cycle > Adolescent Health > Hormonal Contraception EffectsBone Health > Adolescent Bone Development > Contraceptive ImpactContraception/Comparison > Hormonal Contraception > Long-term Reproductive Effects

Apply the Precautionary Principle Concerning Combined Hormonal Contraception Use in Adolescents

Prior JC, 2016 Women's Reproductive Health

Here I respond to Akers, Dhar, and Shah's (2016), Stubbs's (2016), Olshansky's (2016), and Kissling's (2016) commentaries on the article (Prior, 2016) in which I expressed concerns about the potential...

Contraception/Comparison > Hormonal Contraception > Adolescent UseEthics/Philosophy > Precautionary Principle > Pharmaceutical EthicsBone Health > Contraceptive Effects > Adolescent Bone Density

Zika Virus and Birth Defects--Reviewing the Evidence for Causality

Rasmussen SA et al., 2016 The New England Journal of Medicine

The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse pregnancy and birth outcomes, most no...

Pregnancy > Infections > Zika VirusPregnancy > Birth Defects > MicrocephalyDiagnostics > Teratogen Assessment > Causality Criteria