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Was Sampson wrong?

Redwine DB, 2002 Fertility and Sterility
Endometriosis > Pathophysiology > Etiology TheoriesEndometriosis > Pathophysiology > Retrograde Menstruation DebateEthics/Philosophy > Scientific Debate > Disease Causation

Looking below the surface

Boppart S, 2002 SPIE Newsroom
PCOS > Diagnostics > Imaging TechniquesDiagnostics > Imaging > Optical Imaging

Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate

Nilsen J et al., 2001 Endocrinology

Estrogen replacement therapy is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. To compare the impact of therapeutically relevant progestins on estrogen...

Reproductive Endocrinology > Hormone Therapy > Progestin ComparisonPerimenopause/Menopause > Hormone Replacement > NeuroprotectionReproductive Endocrinology > Progesterone > Neuroprotective Effects

Periodic abstinence and calendar method use in Hungary, Peru, the Philippines, and Sri Lanka

d'Arcangues C et al., 2001 Contraception

Focus group research was conducted in four countries to understand how couples who use calendar methods determine when they are at risk of pregnancy, what behavior they adopt during the fertile phase,...

Fertility Awareness > Methods > Calendar/Rhythm MethodFertility Awareness > User Experience > International PerspectivesResearch Methodology > Qualitative Research > Focus Group Studies

Premenstrual dysphoric disorder and risk for major depressive disorder: a preliminary study

Hartlage SA et al., 2001 Journal of Clinical Psychology

Investigators examined whether premenstrual dysphoric disorder (PMDD) poses a risk for major depressive disorder (MDD). In an initial study, women rated premenstrual symptoms and functional impairment...

Menstrual Cycle > Premenstrual Disorders > PMDD and Depression RiskMenstrual Cycle > Mood Disorders > Premenstrual Dysphoric DisorderDiagnostics > Psychiatric Assessment > PMDD Diagnostic Validity

Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis

Janota J et al., 2001 European Journal of Clinical Investigation

BACKGROUND: To determine the influence of chorioamnionitis and neonatal sepsis on procalcitonin (PCT) levels in very-low-birth-weight (VLBW) infants within the first week of life. DESIGN: PCT serum l...

Pregnancy > Complications > ChorioamnionitisDiagnostics > Biomarkers > Neonatal Sepsis MarkersPregnancy > Neonatal Outcomes > Preterm Infant Complications

A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles

Propst AM et al., 2001 Fertility and Sterility

OBJECTIVE: To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET. DESIGN: Randomized, open-label study. SE...

Contraception/Comparison > ART Protocols > Luteal Phase SupportInfertility > IVF > Progesterone SupplementationReproductive Endocrinology > Progesterone > Route of Administration

Angiogenesis in the human corpus luteum: simulated early pregnancy by HCG treatment is associated with both angiogenesis and vessel stabilization

Wulff C et al., 2001 Human Reproduction (Oxford, England)

BACKGROUND: This study examined changes in the luteal vasculature throughout the menstrual cycle and during simulated pregnancy with human chorionic gonadotrophin (HCG) in the human. METHODS: Endothe...

Reproductive Endocrinology > Corpus Luteum > AngiogenesisMenstrual Cycle > Luteal Phase > Vascular ChangesReproductive Endocrinology > HCG > Luteal Rescue Mechanisms

Luteal estrogen supplementation in pregnancies associated with low serum estradiol concentrations

Kaider AS et al., 2001 Early Pregnancy

The role of luteal phase estrogen in pregnancy outcome has been a matter of considerable debate. In order to evaluate the effectiveness of estrogen supplementation in gonadotropin releasing hormone ag...

Reproductive Endocrinology > Estradiol > Luteal Phase SupplementationInfertility > IVF > Luteal Phase SupportPregnancy > Early Pregnancy > Preclinical Pregnancy Loss

Perimenopausal bone loss: more than estrogen depletion

Prior JC et al., 2001 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

To the Editor: In their recent article, "Characterization of Perimenopausal Bone Loss," Recker and colleagues present unique longitudinal bone mineral density (BMD) and hormonal data.1 We acknowledge ...

Perimenopause/Menopause > Bone Health > Perimenopausal Bone LossBone Health > Mechanisms > Progesterone DeficiencyPerimenopause/Menopause > Hormonal Changes > Ovulatory Disturbances

Review of validation studies of the Edinburgh Postnatal Depression Scale

Eberhard-Gran M et al., 2001 Acta Psychiatrica Scandinavica

OBJECTIVE: To review validation studies of the Edinburgh Postnatal Depression Scale (EPDS). METHOD: A systematic search was performed in Medline and the Science Citation Index Expanded (ISI) from the...

Pregnancy > Postpartum > Depression ScreeningPostpartum > Mental Health > Edinburgh Postnatal Depression ScaleResearch Methodology > Systematic Review > Diagnostic Validation

Estradiol/progesterone substitution in the luteal phase improves pregnancy rates in stimulated cycles--but only in younger women

Gleicher N et al., 2001 Early Pregnancy

Innumerable studies have attempted to demonstrate that hormonal support of the luteal phase during ovulation induction cycles improves pregnancy rates. None has, however, so far been able to confirm t...

Reproductive Endocrinology > Estradiol > Luteal Phase SupplementationInfertility > Ovulation Induction > Luteal Phase SupportInfertility > IVF > Age-Related Outcomes

Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic ovary syndrome who was treated with rosiglitazone

Cataldo NA et al., 2001 Fertility and Sterility

OBJECTIVE: To determine the metabolic and reproductive effectiveness of rosiglitazone in polycystic ovary syndrome (PCOS). DESIGN: Case report. SETTING: Academic clinical practice and General Clinic...

PCOS > Treatment > Insulin SensitizersPCOS > Pathophysiology > Insulin ResistanceInfertility > PCOS > Ovulation Restoration

In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome

Child TJ et al., 2001 Fertility and Sterility

OBJECTIVE: To investigate differences in immature oocyte maturation, fertilization, and pregnancy rates among women with unstimulated normal ovaries, polycystic ovaries (PCOs), or PCOS. DESIGN: Prosp...

PCOS > Treatment > In Vitro MaturationInfertility > ART > In Vitro Oocyte MaturationPCOS > Oocyte Quality > Maturation and Fertilization

Validation study of nonsurgical diagnosis of endometriosis

Eskenazi B et al., 2001 Fertility and Sterility

OBJECTIVE: To determine whether the surgical diagnosis of endometriosis can be predicted using symptoms, signs, and ultrasound findings. DESIGN: Prospective study (study sample); retrospective record...

Endometriosis > Diagnosis > Non-Surgical Diagnostic MethodsDiagnostics > Imaging > Transvaginal UltrasoundEndometriosis > Classification > Ovarian vs Non-Ovarian

Effect of metformin on mouse embryo development

Bedaiwy MA et al., 2001 Fertility and Sterility

Polycystic ovary syndrome (PCOS) is a common disorder affecting women of reproductive age. Its cardinal features are hyperandrogenism, chronic anovulation, and infertility. Some of the most important ...

PCOS > Treatment > MetforminInfertility > Ovulation Induction > Drug SafetyResearch Methodology > Animal Models > Mouse Embryo Assay

Oral contraceptive use and bone mineral density in premenopausal women: cross-sectional, population-based data from the Canadian Multicentre Osteoporosis Study

Prior JC et al., 2001 CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne

Background: Positive and negative effects on bone mineral density (BMD) have been described as a result of the premenopausal use of oral contraceptives (OCs); increased fracture rates have also been r...

Contraception/Comparison > Oral Contraceptives > Bone Health EffectsBone Health > Bone Mineral Density > Premenopausal WomenPerimenopause/Menopause > Osteoporosis > Risk Factors

The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada

J D Adachi et al., 2001 Osteoporos Int

Health-related quality of life (HRQL) was examined in relation to prevalent fractures in 4816 community-dwelling Canadian men and women 50 years and older participating in the Canadian Multicentre Ost...

Bone Health > Fractures > Quality of Life ImpactPerimenopause/Menopause > Osteoporosis > Fracture OutcomesResearch Methodology > Epidemiology > Population-Based Studies

Chronobiological basis of female-specific mood disorders

Parry BL et al., 2001 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology

Women have twice the incidence of major depression compared with men. They are prone to develop episodes of depression during times of reproductive hormonal change at puberty, with use of oral contrac...

Reproductive Endocrinology > Hormones and Mood > ChronobiologyMenstrual Cycle > Premenstrual Disorders > Circadian MechanismsPerimenopause/Menopause > Mood Disorders > Hormonal Etiology

Superovulation strategies for assisted reproductive technologies

Davis OK et al., 2001 Seminars in Reproductive Medicine

Assisted reproductive technologies (ART) pregnancy rates improve with the replacement of multiple embryos. The specific number of embryos to be transferred (typically between two and four) is based on...

Reproductive Endocrinology > Ovarian Stimulation > Superovulation ProtocolsInfertility > Assisted Reproduction > IVF StimulationGeneral OB/GYN > Reproductive Medicine > ART Safety

Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction

Albano C et al., 2001 Fertility and Sterility

OBJECTIVE: To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles. DESIGN: Retrospectiv...

Infertility > Ovulation Induction > Multiple Pregnancy PreventionInfertility > Superovulation > Follicular ManagementGeneral OB/GYN > Reproductive Safety > Multiple Gestation Avoidance

Obstetric uses of intravenous immunoglobulin: successes, failures, and promises

Branch DW et al., 2001 The Journal of Allergy and Clinical Immunology

Intravenous immune globulin (IVIG) is approved for use in a number of conditions that may occur in obstetrical patients, including autoimmune thrombocytopenia and immune deficiency syndromes. IVIG als...

Infertility > Recurrent Miscarriage > ImmunotherapyPregnancy > Autoimmune Conditions > Antiphospholipid SyndromePregnancy > Alloimmune Disorders > IVIG Treatment

Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats

Wright DW et al., 2001 Journal of Neurotrauma

Previous animal research suggests that progesterone may have powerful neuroprotective effects in traumatic brain injury (TBI). This experiment tested the hypothesis that progesterone levels correlate ...

Reproductive Endocrinology > Progesterone > NeuroprotectionReproductive Endocrinology > Basic Science > Animal ModelsResearch Methodology > Translational Science > Hormone Effects

Mid-trimester endovaginal sonography in women at high risk for spontaneous preterm birth

Owen J et al., 2001 JAMA

CONTEXT: Although shortened cervical length has been consistently associated with spontaneous preterm birth, it is not known when in gestation this risk factor becomes apparent. OBJECTIVE: To determi...

Pregnancy > Preterm Birth > Cervical Length ScreeningDiagnostics > Ultrasound > Cervical Length MeasurementPregnancy > High-Risk Pregnancy > Preterm Birth Prediction

Treating mental illness in lactating women

Buist A, 2001 Medscape Women's Health

A high prevalence of psychiatric illness has been noted in the postpartum period. Recent research looks to the potential effects of maternal illness during this period on child development. With the p...

Postpartum > Mental Health > Psychotropic Medication in LactationPregnancy > Postpartum Depression > Treatment During BreastfeedingGeneral OB/GYN > Breastfeeding > Medication Safety

Metformin directly inhibits androgen production in human thecal cells

Attia GR et al., 2001 Fertility and Sterility

OBJECTIVE: To examine the direct effect of metformin on thecal cell androgen production. SETTING: Basic science research laboratory, University of Texas Southwestern, Dallas, Texas. INTERVENTION(S):...

PCOS > Pathophysiology > Ovarian Androgen ProductionPCOS > Treatment > Metformin Mechanism of ActionReproductive Endocrinology > Steroidogenesis > Thecal Cell Function

Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome

Yarali H et al., 2001 Fertility and Sterility

OBJECTIVE: To assess cardiac flow parameters in patients with polycystic ovary syndrome (PCOS). DESIGN: A prospective case-control study. SETTING: University-based hospital. PATIENT(S): Thirty cons...

PCOS > Comorbidities > Cardiovascular RiskPCOS > Pathophysiology > Insulin Resistance and Cardiac FunctionDiagnostics > Echocardiography > Diastolic Dysfunction in PCOS

Preterm delivery: a public health perspective

Mattison DR et al., 2001 Paediatric and Perinatal Epidemiology

And his daughter‐in‐law, the wife of Phinehas, was pregnant near to giving birth, and got to hear the report that the ark of the true God was captured and that her father‐in‐law and her husband had di...

Pregnancy > Preterm Birth > Public Health EpidemiologyResearch Methodology > Epidemiology > Perinatal Outcomes

A randomized trial of nurse specialist home care for women with high-risk pregnancies: outcomes and costs

Brooten D et al., 2001 The American Journal of Managed Care

OBJECTIVE: To examine prenatal, maternal, and infant outcomes and costs through 1 year after delivery using a model of prenatal care for women at high risk of delivering low-birth-weight infants in wh...

Pregnancy > High-Risk Pregnancy > Nurse Home Visit InterventionPregnancy > Preterm Birth > Prevention StrategiesResearch Methodology > Randomized Clinical Trial > Prenatal Care Models

Chronological aspects of ultrasonic, hormonal, and other indirect indices of ovulation

Ecochard R et al., 2001 BJOG : an International Journal of Obstetrics and Gynaecology

OBJECTIVE: To improve prediction of ovulation in normal cycles. DESIGN: Collection of women's characteristics and their menstrual cycles. Monitoring and analysis of time relationships between several...

Fertility Awareness > Ovulation Detection > Biomarker ComparisonMenstrual Cycle > Ovulation > Ultrasound and Hormonal IndicesDiagnostics > Ovulation Prediction > Cervical Mucus and Urinary Hormones

Naltrexone effect on pulsatile GnRH therapy for ovulation induction in polycystic ovary syndrome: a pilot prospective study

Fulghesu AM et al., 2001 Journal of Endocrinological Investigation

The aim of the present study was to analyze the opioid influence on LH pulsatility in polycystic ovary syndrome (PCOS) patients and to evaluate the effectiveness of a long-term opioid antagonist (nalt...

PCOS > Treatment > Ovulation Induction and FertilityPCOS > Pathophysiology > Neuroendocrine and Opioid DysfunctionInfertility > Treatment > Hormone Therapy and Pharmacotherapy

[Hormone replacement therapy of menopause, heart and blood vessels]

Kuttenn F et al., 2001 Archives Des Maladies Du Coeur Et Des Vaisseaux

The incidence of coronary heart disease (CHD) is lower in premenopausal women than in men and post-menopausal women of the same age. The higher CHD rate after menopause is currently attributed to estr...

Perimenopause/Menopause > Hormone Therapy > Cardiovascular EffectsPerimenopause/Menopause > Hormone Therapy > Natural Progesterone vs Synthetic ProgestinsContraception/Comparison > Hormonal Agents > Route of Administration Effects

Survival, morbidity, and resource use of infants of 25 weeks' gestational age or less

Chan K et al., 2001 American Journal of Obstetrics and Gynecology

OBJECTIVE: The objective of this study was to examine survival, morbidity, and resource use in a large cohort of extremely preterm infants. STUDY DESIGN: We examined all (n = 754) neonatal intensive ...

Pregnancy > Preterm Birth > Neonatal Outcomes at Extreme PrematurityPregnancy > Neonatal Morbidity > NICU Resource UtilizationResearch Methodology > Cohort Study > Extremely Preterm Infant Survival

Comparison of several one-step home urinary luteinizing hormone detection test kits to OvuQuick

Nielsen MS et al., 2001 Fertility and sterility

Objective: To compare clinical accuracy and ease of use for several of the new rapid one-step home urinary LH detection kits compared with the preexisting OvuQuick brand LH detection kit (designated a...

Fertility Awareness > Ovulation Detection > LH Testing KitsDiagnostics > Hormone Monitoring > Urinary LH DetectionInfertility > Assisted Reproduction > Intrauterine Insemination Timing

A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles

Costabile L et al., 2001 Fertility and Sterility

OBJECTIVE: To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles. DESIGN: Prospective, randomized stu...

Reproductive Endocrinology > Luteal Phase Support > Progesterone AdministrationInfertility > Assisted Reproduction > IVF ProtocolsResearch Methodology > Randomized Controlled Trials > Fertility Treatment

Efficacy of clomiphene citrate and cyclofenil for infertile women with normal ovulatory cycles

Goto S et al., 2001 Fertility and Sterility

Despite the widespread use of clomiphene citrate (CC) for ovulation induction, the pregnancy rates (PRs) in women who take CC are less than expected based on ovulation rates. The causes of this discre...

Infertility > Medical Management > Clomiphene CitrateInfertility > Unexplained Infertility > Ovulation InductionReproductive Endocrinology > Ovulation Induction > Antiestrogenic Effects

A prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection

Aboulghar H et al., 2001 Fertility and Sterility

OBJECTIVE: To compare the karyotype of babies conceived through ICSI with that of naturally conceived babies. DESIGN: Prospective controlled study. SETTING: The Egyptian IVF-ET Center, Cairo, Egypt....

Infertility > Assisted Reproduction > ICSI OutcomesDiagnostics > Genetic Testing > KaryotypingEthics/Philosophy > Assisted Reproduction > Genetic Risks

Psychological correlates of functional hypothalamic amenorrhea

Marcus MD et al., 2001 Fertility and Sterility

OBJECTIVE: To determine whether mood, attitudes, or symptoms of disordered eating discriminated women with functional hypothalamic amenorrhea (FHA) from those with organic causes of amenorrhea and eum...

Reproductive Endocrinology > Hypothalamic Amenorrhea > Psychological FactorsMenstrual Cycle > Anovulation > Stress-Related AmenorrheaGeneral OB/GYN > Amenorrhea > Functional Hypothalamic Amenorrhea

Dietary restraint, exercise, and bone density in young women: are they related?

McLean JA et al., 2001 Medicine and Science in Sports and Exercise

Purpose: Women with high scores for dietary restraint have been found to have higher 24-h urinary cortisol excretion and a higher prevalence of subclinical ovulatory disturbances, both of which may be...

Bone Health > Risk Factors > Dietary RestraintReproductive Endocrinology > Ovulatory Disturbances > Subclinical AnovulationMenstrual Cycle > Ovulatory Disturbances > Metabolic Factors

Expert in fertility appreciation: the Creighton Model practitioner

Barron ML et al., 2001 Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN

The Creighton Model system of natural family planning (NFP) is useful in achieving pregnancy, avoiding pregnancy, and detecting some gynecologic disorders. NFP practitioners support the client in usin...

NaProTECHNOLOGY > Creighton Model System > Practitioner TrainingFertility Awareness > Education > NFP Instruction MethodsBody Literacy > Professional Support > NFP Practitioner Role

Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study

Sutcliffe AG et al., 2001 Lancet (London, England)

BACKGROUND: There have been reports suggesting that children born after in-vitro fertilisation by intracytoplasmic sperm injection (ICSI) are at increased risk of neurodevelopmental delay. We have und...

Infertility > Assisted Reproduction > ICSI Child OutcomesAndrology > Male Factor Infertility > ICSI Offspring HealthEthics/Philosophy > Assisted Reproduction > Developmental Outcomes

Blood loss following noncomplicated transvaginal oocyte retrieval for in vitro fertilization

Dessole S et al., 2001 Fertility and Sterility

Transvaginal ultrasonic follicle puncture has now become the method of choice for oocyte retrieval among most in vitro fertilization (IVF) units. The procedure, which involves puncture then aspiration...

Infertility > Assisted Reproduction > IVF ComplicationsSurgery > Transvaginal Procedures > Oocyte RetrievalGeneral OB/GYN > Surgical Complications > Hemorrhage Assessment