Propst, A. M., Hill, J. A., Ginsburg, E. S., Hurwitz, S., Politch, J., & Yanushpolsky, E. H. (2001). A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Fertility and Sterility, 76(6), 1144-1149. https://doi.org/10.1016/s0015-0282(01)02872-2
Propst AM, Hill JA, Ginsburg ES, Hurwitz S, Politch J, Yanushpolsky EH. A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Fertil Steril. 2001;76(6):1144-1149. doi:10.1016/s0015-0282(01)02872-2
Propst, Anthony M., et al. "A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles." Fertility and Sterility, vol. 76, no. 6, 2001, pp. 1144-1149.
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To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET.
Design
Randomized, open-label study.
Setting
Academic medical center.
Patients
Two hundred and one women undergoing IVF-ET.
Interventions
Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval.
Main Outcome Measures
Pregnancy, embryo implantation, and live birth rates.
Results
The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio [OR], 2.16; 95% confidence interval [CI], 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%.
Conclusions
In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone.
Pregnancy › Early Pregnancy › Progesterone Support · Therapeutics › Hormonal Agents › Progesterone and Progestins · Assisted Reproduction › Add-Ons and Adjuncts › Adjunct Evidence Base
Anthony M Propst, Joseph A Hill, Elizabeth S Ginsburg, Shelley Hurwitz, Joseph Politch, Elena H Yanushpolsky
Tony Propst, A Propst, Joe Hill, Joey Hill, J Hill, Liz Ginsburg, Beth Ginsburg, Betsy Ginsburg, E Ginsburg, S Hurwitz, Joe Politch, Joey Politch, J Politch, E Yanushpolsky
PMID 11730742 11730742 DOI 10.1016/s0015-0282(01)02872-2 10.1016/s0015-0282(01)02872-2 Propst et al. 2001, Propst 2001
