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Annual summary of vital statistics--2001

March of Dimes, 2001 Pediatrics

The number of births, the crude birth rate (14.5 in 2001), and the fertility rate (67.2 in 2001) all declined slightly (by 1% or less) from 2000 to 2001. Fertility rates were highest for Hispanic wome...

Pregnancy > Epidemiology > National Birth StatisticsGeneral OB/GYN > Public Health > Maternal Child Health OutcomesPregnancy > Complications > Preterm Birth Epidemiology

Comparison of LH concentrations in the early and mid-luteal phase in IVF cycles after treatment with HMG alone or in association with the GnRH antagonist Cetrorelix

Tavaniotou A et al., 2001 Human reproduction (Oxford, England)

Luteinizing hormone (LH) is mandatory for the maintenance of the corpus luteum. Ovarian stimulation for IVF has been associated with a defective luteal phase. The luteal phases of two groups of patien...

Infertility > Assisted Reproduction > IVF Luteal Phase SupportReproductive Endocrinology > Gonadotropins > LH Luteal FunctionInfertility > Assisted Reproduction > GnRH Antagonist Protocols

Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women

Rosano GM et al., 2000 Journal of the American College of Cardiology

OBJECTIVES: We sought to compare the effects of estrogen/transvaginal progesterone gel with estrogen/medroxyprogesterone acetate (MPA) on exercise-induced myocardial ischemia in postmenopausal women w...

Perimenopause/Menopause > Hormone Replacement Therapy > Progesterone vs ProgestinsReproductive Endocrinology > Progesterone > Cardiovascular EffectsResearch Methodology > Clinical Trials > Randomized Crossover Design

Cognitive dietary restraint is associated with higher urinary cortisol excretion in healthy premenopausal women

McLean JA et al., 2000 The American Journal of Clinical Nutrition

Background: Cognitive dietary restraint, assessed by the Three-Factor Eating Questionnaire restraint subscale, is associated with subclinical menstrual cycle disturbances. This association may be medi...

Menstrual Cycle > Ovulatory Disturbances > Stress and Dietary RestraintBone Health > Risk Factors > Cortisol and Calcium ExcretionReproductive Endocrinology > Hypothalamic Function > Energy Balance and Stress

Thyroid disease and female reproduction

Krassas GE, 2000 Fertility and Sterility

OBJECTIVE: To review the menstrual function and fertility in thyroid disease, mainly in hyperthyroidism and hypothyroidism. Also to register the consequences of (131)I therapy, which is used widely in...

Reproductive Endocrinology > Thyroid Disorders > Menstrual DisturbancesInfertility > Endocrine Causes > Thyroid DysfunctionGeneral OB/GYN > Endocrine Disorders > Thyroid Disease and Reproduction

Common genetic changes between endometriosis and ovarian cancer

Obata K et al., 2000 Gynecologic and Obstetric Investigation

We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the o...

Endometriosis > Malignant Transformation > Genetic MechanismsEndometriosis > Pathophysiology > Loss of Heterozygosity and PTENGeneral OB/GYN > Gynecologic Oncology > Endometriosis-Associated Ovarian Cancer

Evidence that endometriosis behaves in a malignant manner

Thomas EJ et al., 2000 Gynecologic and Obstetric Investigation

It is well known that certain aspects of endometriosis are similar to those of malignant disease. For example, like cancer, endometriosis can be both locally and distantly metastatic; it attaches to o...

Endometriosis > Malignant Transformation > Clinical EvidenceEndometriosis > Pathophysiology > Invasion and Metastatic BehaviorGeneral OB/GYN > Gynecologic Oncology > Endometriosis Cancer Risk

Prevalence of endometriosis in ovarian cancer

Yoshikawa H et al., 2000 Gynecologic and Obstetric Investigation

Endometriosis may be the precursor of clear cell or endometrioid ovarian cancer. In this review, we focus on the prevalence of endometriosis in ovarian cancer and related clinical and epidemiological ...

Endometriosis > Malignant Transformation > Ovarian Cancer PrevalenceEndometriosis > Epidemiology > Geographic and Histologic VariationGeneral OB/GYN > Gynecologic Oncology > Endometriosis-Associated Ovarian Cancer

Malignant transformation of ovarian endometriosis

Nishida M et al., 2000 Gynecologic and Obstetric Investigation

One hundred forty-seven cases of ovarian endometriosis, encountered from 1976 to 1999 at Tsukuba University Hospital, were studied to clarify the incidence of malignant transformation. There were 18 c...

Endometriosis > Malignant Transformation > Incidence and RiskEndometriosis > Pathophysiology > Atypical Endometriosis ProgressionGeneral OB/GYN > Gynecologic Oncology > Ovarian Cancer from Endometriosis

Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review

Dimmock PW et al., 2000 Lancet (London, England)

BACKGROUND: Selective serotonin-reuptake inhibitors (SSRIs) are increasingly being used as first-line therapy for severe premenstrual syndrome (PMS). We undertook a meta-analysis on the efficacy of SS...

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentMenstrual Cycle > Premenstrual Syndrome > SSRI TherapyResearch Methodology > Systematic Review > Meta-Analysis

Induction of Ovarian Follicle Development and Ovulation with Exogenous Gonadotropins: A Technical Bulletin by American Society for Reproductive Medicine

American Society for Reproductive Medicine, 1998 Journal of assisted reproduction and genetics

Purpose: A large part of infertility treatment involves the use of exogenous gonadotropins. The last decade has seen a progressive switch from human menopausal gonadotropin (hMG), the original gonadot...

Reproductive Endocrinology > Ovulation Induction > Gonadotropin ProtocolsInfertility > Treatment > Ovarian StimulationReproductive Endocrinology > Pharmacology > FSH vs hMG Comparison

Serial salivary estriol to detect an increased risk of preterm birth

Heine RP et al., 2000 Obstetrics and Gynecology

OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 w...

Pregnancy > Preterm Birth > Biomarker ScreeningDiagnostics > Salivary Hormones > Estriol MeasurementPregnancy > Preterm Labor > Risk Prediction

Polycystic ovary syndrome: it's not just infertility

Hunter MH et al., 2000 American Family Physician

Recent diagnostic and pharmacologic developments have focused renewed attention on polycystic ovary syndrome. Clinical features of the syndrome include anovulation, hyperandrogenism and menstrual dysf...

PCOS > Diagnosis > Clinical FeaturesPCOS > Metabolic Complications > Cardiovascular RiskPCOS > Treatment > Comprehensive Management

Oral contraceptives and the incidence of multiple sclerosis

Hernán MA et al., 2000 Neurology

Background: Experimental and clinical data suggest a protective effect of estrogens on the development and progression of MS. Methods: We assessed whether MS incidence was associated with oral contra...

Contraception/Comparison > Side Effects > Neurological Disease RiskContraception/Comparison > Oral Contraceptives > Multiple Sclerosis AssociationResearch Methodology > Prospective Cohort > Large Population Studies

Menstrual cycle symptom variation in a community sample of women using and not using oral contraceptives

Sveinsdóttir H et al., 2000 Acta Obstetricia Et Gynecologica Scandinavica

BACKGROUND: The prevalence of significant symptom change (symptom cyclicity) prospectively rated over multiple menstrual cycles has not been established in a non-clinical population. METHODS: Seventy...

Menstrual Cycle > Premenstrual Syndrome > Symptom CyclicityContraception/Comparison > Oral Contraceptives > Menstrual Symptom EffectsMenstrual Cycle > Symptom Tracking > Prospective Daily Ratings

Subfertility and risk of spontaneous abortion

Gray RH et al., 2000 American Journal of Public Health

OBJECTIVES: The purpose of this study was to assess the association between subfertility and spontaneous abortion. METHODS: A total of 1572 women in New York and Vermont reported 3269 pregnancies bet...

InfertilityPregnancy

Vertebral fracture definition from population-based data: preliminary results from the Canadian Multicenter Osteoporosis Study (CaMos)

SA Jackson et al., 2000 Osteoporos Int

The Canadian Multicenter Osteoporosis Study is a large population-based prospective study of osteoporosis in the Canadian population. The study involves 9424 subjects, both male and female, from nine ...

Bone Health > Osteoporosis > Vertebral Fracture PrevalenceBone Health > Diagnostics > Spinal MorphometryResearch Methodology > Prospective Cohort > Population-Based Studies

Effectiveness of a Standard-Rule Method of Calendar Rhythm among Mayan Couples in Guatemala

Burkhart MC et al., 2000 International family planning perspectives

Mayan couples in Guatemala have very low rates of contraceptive use but have long expressed an interest in natural family planning methods. A simple calendar rhythm method of family planning was teste...

Fertility Awareness > Calendar Methods > Standard Days MethodFertility Awareness > Effectiveness > Prospective StudiesFertility Awareness > Acceptability > Developing Country Populations

Change in cervical length after cerclage as a predictor of preterm delivery

Dijkstra K et al., 2000 Obstetrics and Gynecology

OBJECTIVE: To determine whether the degree of cervical lengthening after cerclage and whether serial follow-up measurements of cervical length after cerclage are predictive of pregnancy outcome. METH...

Pregnancy > Preterm Birth > Cerclage OutcomesPregnancy > Cervical Insufficiency > Ultrasound MonitoringDiagnostics > Transvaginal Ultrasound > Cervical Length Measurement

Effects of estrogen replacement on the progression of coronary-artery atherosclerosis

Herrington DM et al., 2000 The New England Journal of Medicine

BACKGROUND: Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about i...

Perimenopause/Menopause > Hormone Replacement > Cardiovascular EffectsGeneral OB/GYN > Hormone Therapy > Coronary Disease PreventionResearch Methodology > Randomized Controlled Trial > Angiographic Endpoints

Peripheral metabolism of thyroid hormones: a review

Kelly GS, 2000 Alternative Medicine Review : a Journal of Clinical Therapeutic

Peripheral metabolism of thyroid hormones is a critical component of the impact these hormones have on intracellular function. Thyroid hormones can be metabolized in peripheral tissue by deiodination,...

Reproductive Endocrinology > Thyroid Disorders > Peripheral Thyroid Hormone MetabolismReproductive Endocrinology > Thyroid Disorders > Low T3 SyndromeDiagnostics > Thyroid Function Testing > Thyroid Hormone Conversion

Canadian normative data for the SF-36 health survey. Canadian Multicentre Osteoporosis Study Research Group

WM Hopman et al., 2000 CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne

Background: The Medical Outcomes Study 36-item Short Form (SF-36) is a widely used measure of health-related quality of life. Normative data are the key to determining whether a group or an individual...

Research Methodology > Outcome Measures > Health-Related Quality of LifeBone Health > Osteoporosis > Population-Based Screening Studies

Non-steroidal anti-inflammatory drugs as a possible cause for reversible infertility

Mendonça LL et al., 2000 Rheumatology (Oxford, England)

OBJECTIVE: To highlight the possible association between infertility and treatment with long-term non-steroidal anti-inflammatory drug (NSAIDs). NSAIDs act mainly through the inhibition of cyclooxygen...

Infertility > Female Factors > Drug-Induced InfertilityInfertility > Treatment > Medication ModificationGeneral OB/GYN > Pharmacology > NSAIDs and Reproductive Outcomes

Perineal endometriosis with anal sphincter involvement: report of a case

Dougherty LS et al., 2000 Diseases of the Colon and Rectum

INTRODUCTION: Perineal endometriosis with anal sphincter involvement is an infrequent occurrence. Wide excision is the best chance of cure of perineal endometriosis but may cause incontinence when the...

Endometriosis > Extrapelvic Endometriosis > Perineal EndometriosisSurgery > Excision Techniques > Wide Excision and SphincteroplastyEndometriosis > Surgical Management > Recurrence After Excision

Profile and opinions of the female Persona user in The Netherlands

Janssen CJ et al., 2000 The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception

Objectives: The primary objective of this study was to investigate the profile of the Dutch Persona user and her opinion about this relatively new way of natural birth control. The results of the stud...

Fertility Awareness > Methods > Hormone Monitoring DevicesBody Literacy > Cycle Awareness > Fertility Monitor UseContraception/Comparison > Natural Methods > User Profiles and Satisfaction

The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System

Kramer MS et al., 2000 JAMA

CONTEXT: The World Health Organization defines preterm birth as birth at less than 37 completed gestational weeks, but most studies have focused on very preterm infants (birth at <32 weeks) because of...

Pregnancy > Preterm Birth > Infant Mortality RiskPregnancy > Neonatal Outcomes > Late Preterm Birth ConsequencesResearch Methodology > Epidemiology > Population-Based Cohort Studies

Multiple gestation: reflections on epidemiology, causes, and consequences

Keith LG et al., 2000 International Journal of Fertility and Women's Medicine

Multiple births (of all orders) increased in epidemic proportions in the years 1971-1997. Twins increased 53%, 32%, 31%, and 83% in white, Afro-American, Native American and Mexican American women, re...

Pregnancy > Multiple Gestation > Epidemiology and TrendsPregnancy > Multiple Gestation > Neonatal OutcomesInfertility > ART Complications > Multiple Pregnancy Risk

Disposition of extra embryos

Beyler SA et al., 2000 Fertility and Sterility

Contemporary practice in assisted reproductive technologies (ART) compensates for the attrition that occurs at each phase of the cycle. Every follicle does not yield an egg, nor does every egg fertili...

Contraception/Comparison > ART > Embryo DispositionEthics/Philosophy > Reproductive Ethics > Status of EmbryosInfertility > ART > Embryo Transfer Practices

Infertility is a symptom, not a disease

Dickey RP et al., 2000 Fertility and Sterility

In an otherwise excellent editorial that appeared in this journal concerning the problems created by failure of the Health Insurance Industry to provide coverage for infertility, the author, a noted a...

Infertility > Diagnosis > Underlying Disease IdentificationEthics/Philosophy > Medical Philosophy > Infertility as SymptomRRM Methods > Principles > Root Cause Diagnosis of Infertility

Laparoscopy in the "normal" infertile patient: a question revisited

Corson SL et al., 2000 The Journal of the American Association of Gynecologic Laparoscopists

STUDY OBJECTIVE: To determine the prevalence of reproductive pathology in a group of infertile women thought to be at low risk for altered pelvic anatomy. DESIGN: Retrospective chart review and follo...

Infertility > Diagnosis > Diagnostic LaparoscopyEndometriosis > Diagnosis > Laparoscopic Detection in Infertile WomenSurgery > Diagnostic Procedures > Laparoscopy in Unexplained Infertility

Contribution of assisted reproductive technology and ovulation-inducing drugs to triplet and higher-order multiple births--United States, 1980-1997

CDC, 2000 MMWR. Morbidity and Mortality Weekly Report

In the United States, pregnancies associated with assisted reproductive technology (ART) or ovulation-inducing drugs are more likely to result in multiple births than spontaneously conceived pregnanci...

Infertility > Assisted Reproductive Technology > Multiple Pregnancy OutcomesInfertility > Assisted Reproductive Technology > Epidemiology and TrendsGeneral OB/GYN > Neonatal Outcomes > Preterm Birth

Gonadotropin-releasing hormone-stimulated sperm binding to the human zona is mediated by a calcium influx

Morales P et al., 2000 Biology of reproduction

The mechanism by which GnRH increases sperm-zona pellucida binding in humans was investigated in this study. We tested whether GnRH increases sperm-zona binding in Ca(2+)-free medium and in the presen...

Andrology > Sperm Function > Zona Pellucida BindingReproductive Endocrinology > GnRH Signaling > Sperm Calcium ChannelsAndrology > Sperm Physiology > Calcium Signaling

Population-based screening for postpartum depression

Georgiopoulos AM et al., 2000 Obstetrics and Gynecology

OBJECTIVE: To estimate the community prevalence in Olmsted County, Minnesota of elevated scores on the Edinburgh Postnatal Depression Scale, a self-report screening tool for postpartum depression. ME...

Postpartum > Mental Health > Depression ScreeningPregnancy > Postpartum Care > Depression PrevalenceDiagnostics > Screening Tools > Edinburgh Postnatal Depression Scale

Oral contraceptives and fatal pulmonary embolism

Parkin L et al., 2000 Lancet (London, England)

In a national case-control study of fatal pulmonary embolism in New Zealand women of childbearing age, we estimated that current users of combined oral contraceptives had a relative risk of 9.6 (95% C...

Contraception/Comparison > Oral Contraceptives > Venous ThromboembolismContraception/Comparison > Adverse Effects > Pulmonary Embolism MortalityResearch Methodology > Study Design > Case-Control Study

Comparison of regimens containing oral micronized progesterone or medroxyprogesterone acetate on quality of life in postmenopausal women: a cross-sectional survey

Fitzpatrick LA et al., 2000 Journal of Women's Health & Gender-based Medicine

A cross-sectional survey was conducted to examine quality of life (QOL) related to physiological, somatic, and vasomotor effects of changing progestogen treatment from medroxyprogesterone acetate (MPA...

Perimenopause/Menopause > Hormone Replacement Therapy > Progestogen ComparisonPerimenopause/Menopause > Symptoms > Quality of Life AssessmentReproductive Endocrinology > Progesterone > Micronized vs Synthetic

The importance of user compliance on the effectiveness of natural family planning programs

Tommaselli GA et al., 2000 Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology

Nowadays, there is an increasing interest in natural family planning methods. The biological basis for the application of natural family planning methods is the recognition of ovulation and, more exte...

Fertility Awareness > Method Effectiveness > User ComplianceFertility Awareness > Natural Family Planning > Discontinuation RatesResearch Methodology > Literature Review > NFP Effectiveness

Avoiding multiple pregnancies in ART: consideration of new strategies

Hazekamp J et al., 2000 Human Reproduction (Oxford, England)

To maximize pregnancy rates, physicians who perform IVF, often transfer multiple embryos, which increases the multiple birth risk. Multiple birth infants are at significant risk for a number of advers...

Contraception/Comparison > Assisted Reproductive Technology > Multiple Birth PreventionInfertility > IVF > Embryo Transfer StrategiesEthics/Philosophy > ART > Multiple Pregnancy Reduction

Increased adverse pregnancy outcomes with unreliable last menstruation

Nguyen TH et al., 2000 Obstetrics and Gynecology

OBJECTIVE: To estimate the risk of adverse outcomes in women whose first day of the last menstrual period (LMP) was unreliable. METHODS: Among 20,244 singleton pregnancies with measurements of bipari...

Pregnancy > Gestational Dating > Last Menstrual Period ReliabilityPregnancy > Adverse Outcomes > Stillbirth and Preterm BirthMenstrual Cycle > Cycle Regularity > Pregnancy Dating Implications

Treatment of Preterm Labor with Human Chorionic Gonadotropin: A New Modality

Ali AFM et al., 2000 Obstetrics & Gynecology

Background: Previous studies have demonstrated that human myometrium contains receptors for human chorionic gonadotropin (hCG) and that hCG can inhibit myometrial contractions in vitro. Objective: To...

Pregnancy > Preterm Labor > hCG Tocolytic TherapyReproductive Endocrinology > hCG > Myometrial EffectsResearch Methodology > Study Design > Randomized Controlled Trial

Effects of gonadal steroids in women with a history of postpartum depression

Bloch M et al., 2000 The American Journal of Psychiatry

OBJECTIVE: Endocrine factors are purported to play a role in the etiology of postpartum depression, but direct evidence for this role is lacking. The authors investigated the possible role of changes ...

Reproductive Endocrinology > Gonadal Steroids > Postpartum Depression EtiologyPostpartum > Mental Health > Hormonal SensitivityPerimenopause/Menopause > Hormone Withdrawal > Mood Effects

Amniotic fluid interleukin-6 and preterm delivery: a review

El-Bastawissi AY et al., 2000 Obstetrics and Gynecology

OBJECTIVE: To evaluate the potential role of amniotic fluid (AF) interleukin (IL)-6 as a predictor of preterm delivery and to consider possible explanations for the proportion of women with elevated A...

Pregnancy > Preterm Birth > Biomarkers and PredictionPregnancy > Preterm Birth > Intra-amniotic InfectionDiagnostics > Inflammatory Markers > Interleukin-6

Effects of in vitro fertilization on low birth weight, preterm delivery, and multiple birth

Tough SC et al., 2000 The Journal of Pediatrics

PURPOSE: To quantify the contribution of in vitro fertilization (IVF) on changes in the rates of low birth weight (LBW), preterm delivery, very low birth weight, and multiple births during the past 3 ...

Pregnancy > Preterm Birth > ART-Related PrematurityInfertility > ART Outcomes > Neonatal ComplicationsPregnancy > Multiple Pregnancy > IVF-Related Multiple Birth

Characteristics of women associated with continuing instruction in the Creighton Model Fertility Care System

Smith KR et al., 2000 Contraception

Effective use of natural family planning is strongly dependent upon adequate instruction. The Creighton Model Fertility Care System (CrMS) has a standardized protocol for instruction of new users that...

NaProTECHNOLOGY > Creighton Model System > User Education and ComplianceFertility Awareness > Method Instruction > Follow-up and RetentionBody Literacy > Fertility Charting > User Demographics

Barrier agents for preventing adhesions after surgery for subfertility

Wiseman D et al., 2000 The Cochrane Database of Systematic Reviews

Background: Pelvic adhesions can be the result of inflamation, endometriosis or surgical trauma. Prevention of postoperative adhesions (either new or reoccurance) has been postulated by using barriers...

Surgery > Adhesion Prevention > Barrier AgentsInfertility > Surgical Treatment > Postoperative Adhesion PreventionResearch Methodology > Systematic Reviews > Cochrane Reviews