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Fertility Awareness-Based Methods for Family Planning and Women's Health: Impact of an Online Elective

Duane M et al., 2024 Open Access Family Medicine

BACKGROUND AND Objectives: Fertility awareness-based methods (FABMs) are evidence-based means of tracking observable biomarkers of a woman's fertility for the purpose of reproductive health monitoring...

Fertility Awareness > Education > Medical TrainingRRM Methods > Medical Education > Curriculum DevelopmentBody Literacy > Healthcare Provider Training > FABM Knowledge

Gastrointestinal Myoelectrical Activity (GIMA) Biomarker for Noninvasive Diagnosis of Endometriosis

Noar M et al., 2024 Open Access Journal of Clinical Medicine

Background/Objectives: Endometriosis represents substantial direct and indirect healthcare costs impacted by an absence of uniformly accurate, non-invasive diagnostic tools. We endeavored to demonstra...

Endometriosis > Diagnostics > Noninvasive BiomarkersDiagnostics > Novel Methods > Gastrointestinal Myoelectrical ActivityEndometriosis > Pathophysiology > GI Involvement

Analysis of factors affecting pregnancy rate after laparoscopic surgery for infertility associated with endometriosis

Zhang J et al., 2024 Open Access European Journal of Obstetrics, Gynecology, and Reproductive Biology

Objective: To analyze the factors that might influence the pregnancy rate in patients with infertility related to endometriosis (EMs) after undergoing laparoscopic surgery, providing guidance for our ...

Endometriosis > Treatment > Laparoscopic Surgery OutcomesInfertility > Female Factor > Endometriosis-Related InfertilitySurgery > Laparoscopy > Prognostic Factors

Isthmocele and Infertility

Baldini GM et al., 2024 Open Access Journal of Clinical Medicine

Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or ins...

Infertility > Uterine Factors > IsthmoceleSurgery > Hysteroscopic > Cesarean Scar Defect RepairGeneral OB/GYN > Cesarean Complications > Scar Niche

Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy

Ciwun M et al., 2024 Open Access Cancers

Naltrexone (NTX) is a non-selective antagonist of opioid receptors, primarily used in the therapy of opioid and alcohol dependence. Low-dose naltrexone (LDN) exhibits antagonistic action against the o...

General OB/GYN > Pharmacology > Low-Dose NaltrexoneRRM Methods > Adjunct Therapies > LDN ImmunomodulationResearch Methodology > Systematic Reviews > Drug Repurposing

Successful pregnancy using oral DHEA treatment for hypoandrogenemia in a 30-year-old female with 5 recurrent miscarriages, including fetal demise at 24 weeks: a case report

Boyle PC et al., 2024 Open Access Frontiers in Medicine

Hypoandrogenemia is not usually considered as a potential cause of recurrent miscarriage. We present the case of a 30-year-old female with 6 previous pregnancies resulting in one live birth and 5 preg...

NaProTECHNOLOGY > Treatment > Hormonal SupplementationPregnancy > Recurrent Loss > DHEA TreatmentReproductive Endocrinology > Androgen Deficiency > Female

Male Infertility

Leslie SW et al., 2024 StatPearls [Internet]

Infertility is usually defined as the inability of a couple to conceive even after 1 year of unprotected, frequent sexual intercourse. It affects about 15% of all couples in the United States and at l...

Andrology > Male Infertility > Overview and EvaluationInfertility > Male Factor > Causes and TreatmentDiagnostics > Male Reproductive Assessment > Semen Analysis

An artificial intelligence approach for investigating multifactorial pain-related features of endometriosis

Kiser AC et al., 2024 Open Access PloS one

Endometriosis is a debilitating, chronic disease that is estimated to affect 11% of reproductive-age women. Diagnosis of endometriosis is difficult with diagnostic delays of up to 12 years reported. T...

Endometriosis > Symptoms > Pain CharacterizationDiagnostics > Artificial Intelligence > Pain PhenotypingResearch Methodology > Machine Learning > Clinical Applications

Longitudinal Assessment of Bone Mineral Density in Women Living With and Without HIV Across Reproductive Phases

Swann SA et al., 2024 Journal of acquired immune deficiency syndromes (1999)

Background: Women living with HIV commonly experience low areal bone mineral density (BMD), but whether this is affected by low ovarian hormonal states (prolonged amenorrhea or menopause) is unknown. ...

Bone Health > Bone Mineral Density > HIV and MenopausePerimenopause/Menopause > Bone Health > BMD MonitoringReproductive Endocrinology > Ovarian Hormones > Bone Effects

The Prevalence of Endometriosis in Patients with Unexplained Infertility

Nezhat C et al., 2024 Open Access Journal of Clinical Medicine

Endometriosis, a systemic ailment, profoundly affects various aspects of life, often eluding detection for over a decade. This leads to enduring issues such as chronic pain, infertility, emotional str...

Endometriosis > Diagnostics > Prevalence in Unexplained InfertilityInfertility > Unexplained > Endometriosis AssociationSurgery > Diagnostic Laparoscopy > Endometriosis Detection

The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States

Sharma M et al., 2024 Open Access Journal of Perinatology : Official Journal of the California Perinatal Association

Objective: To determine the association between fertility treatment, socioeconomic status (SES), and neonatal and post-neonatal mortality. STUDY Design: Retrospective cohort study of all births (19,3...

Infertility > ART Outcomes > Neonatal MortalityPregnancy > Neonatal Outcomes > ART and Socioeconomic StatusEthics/Philosophy > ART Safety > Infant Health Outcomes

The menstrual cycle is influenced by weekly and lunar rhythms

Ecochard R et al., 2024 Open Access Fertility and Sterility

Objective: To study whether the menstrual cycle has a circaseptan (7 days) rhythm and whether it is associated with the lunar cycle (also defined as the synodic month, it is the cycle of the phases of...

Menstrual Cycle > Cycle Characteristics > Circaseptan and Circalunar RhythmsFertility Awareness > Cycle Patterns > Menstrual Onset TimingResearch Methodology > Cross-Sectional Studies > Large Population Analysis

Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming

Lu C et al., 2024 International Journal of Molecular Sciences

Studies have shown that the occurrence and development of endometriosis are closely linked to long-term psychological stress. The specific contribution of chronic stress to the metabolic adaptations i...

Endometriosis > Pathophysiology > Stress and Immune ResponseEndometriosis > Risk Factors > Psychological StressReproductive Endocrinology > Psychoneuroimmunology > Endometriosis

Prevalence and risk factors for postpartum depression 2 months after a vaginal delivery: a prospective multicenter study

Froeliger A et al., 2024 American Journal of Obstetrics and Gynecology

Background: Very little is known about the prevalence and risk factors of postpartum depression among women with vaginal births without major pregnancy complications. Objective: This study aimed to a...

Postpartum > Mental Health > Postpartum Depression Risk FactorsPregnancy > Delivery Outcomes > Vaginal Delivery ComplicationsResearch Methodology > Prospective Cohort Studies > Multicenter Trials

Sperm DNA fragmentation index affect pregnancy outcomes and offspring safety in assisted reproductive technology

Li F et al., 2024 Open Access Scientific Reports

The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of ...

Andrology > Sperm Quality > DNA FragmentationInfertility > Male Factor > Sperm DNA IntegrityInfertility > ART Outcomes > Offspring Safety

Experiences of women living with Polycystic Ovary Syndrome: A pilot case-control, single-cycle, daily Menstrual Cycle Diary study during the SARS-CoV-2 pandemic

Nelson K et al., 2024 Open Access PloS One

Polycystic Ovary Syndrome (PCOS) affects many people and is often distressing. Much medical literature about diagnosis and treatment exists, but little is known about PCOS menstrual cycle-related expe...

PCOS > Patient Experience > Daily Symptom TrackingMenstrual Cycle > Assessment > Daily Diary MethodPCOS > Diagnostics > Cycle-Based Monitoring

Photobiomodulation therapy at 632 nm wavelength ameliorates intrauterine adhesion via activation of cAMP/PKA/CREB pathway

Zheng H et al., 2024 Photochemistry and Photobiology

Intrauterine adhesion (IUA), a major cause of uterine infertility, is pathologically characterized by endometrial fibrosis. Current treatments for IUA have poor efficacy with high recurrence rate, and...

Surgery > Intrauterine Adhesion Treatment > PhotobiomodulationInfertility > Uterine Factor > Asherman Syndrome TreatmentReproductive Endocrinology > Endometrial Pathology > Fibrosis Mechanisms

PCOS stratification for precision diagnostics and treatment

Joshi A, 2024 Frontiers in Cell and Developmental Biology

Globally, polycystic ovarian syndrome (PCOS) affects approximately 10% of fertile women, leading to great health and economic burden. PCOS is a heterogenous illness that can cause infertility, irregul...

PCOS > Classification > Precision PhenotypingPCOS > Treatment > Personalized MedicineDiagnostics > Stratification > PCOS Subtypes

mHealth technologies for pregnancy prevention: A challenge for patient-centred contraceptive counselling in Dutch general practice

Algera E et al., 2024 The European journal of general practice

BACKGROUND: A general practitioner (GP) standardly provides contraceptive counselling and care in the Netherlands. Recent years have seen the rise of mobile health technologies that aim to prevent pre...

Fertility Awareness > Technology > Mobile Health AppsContraception/Comparison > Digital Tools > App-Based MethodsBody Literacy > Healthcare Provider Training > Digital Counselling

Fraction of cancers attributable to and prevented by reproductive factors and exogenous hormones use in Italy

Turati F et al., 2024 European journal of obstetrics, gynecology, and reproductive biology

OBJECTIVE: Endogenous and exogenous hormonal factors have been associated with female breast, genital, and colorectal cancer risk. The aim of the present study is to conduct an evidence-based evaluati...

Contraception/Comparison > Oral Contraceptives > Cancer Risk and PreventionGeneral OB/GYN > Cancer Epidemiology > Reproductive and Hormonal FactorsResearch Methodology > Epidemiologic Design > Population Attributable Fraction

Protective effects of engineered Lactobacillus crispatus strains expressing G-CSF on thin endometrium of mice

Liu S et al., 2024 Human reproduction (Oxford, England)

STUDY QUESTION: Does recombinant Lactobacillus expressing granulocyte colony-stimulating factor (G-CSF) have a better protective effect than the current treatment of thin endometrium (TE)? SUMMARY AN...

Surgery > Endometrial Repair > Thin Endometrium TreatmentInfertility > Endometrial Factors > Thin EndometriumGeneral OB/GYN > Uterine Microbiome > Lactobacillus Therapy

Outcomes of fetal lower urinary tract obstruction based on timing of oligohydramnios onset

Munoz JL et al., 2023 Prenatal Diagnosis

Objective: Fetal Lower Urinary Tract Obstruction (LUTO) is associated with oligohydramnios and significant fetal morbidity, resulting in poor lung development and perinatal death. However, oligohydram...

Pregnancy > Fetal Anomalies > Lower Urinary Tract ObstructionGeneral OB/GYN > Prenatal Diagnosis > Oligohydramnios OutcomesResearch Methodology > Retrospective Cohort Studies > Perinatal Outcomes

The Impact of Irregular Menstruation on Health: A Review of the Literature

Attia GM et al., 2023 Open Access Cureus

Women are considered to have an irregular menstrual cycle if their cycle length is less than 21 days or more than 35 days, accompanied by less or very severe blood flow. The prevalence of menstrual cy...

Menstrual Cycle > Disorders > Health Impact ReviewBody Literacy > Menstrual Health > Vital Sign IndicatorGeneral OB/GYN > Women's Health > Menstrual Irregularity Outcomes

Fertility after expanded polytetrafluoroethylene use after endometrioma cystectomy: a pilot study

Yeung PP Jr et al., 2023 Open Access Frontiers in Reproductive Health

Introduction: Pregnancy rates after the placement of expanded polytetrafluoroethylene (ePTFE, trade name Gore-Tex®) for adhesion prevention following cystectomy of endometriomas ≥3 cm and excision of ...

Endometriosis > Treatment > Surgical TechniquesSurgery > Adhesion Prevention > ePTFE BarrierInfertility > Ovarian Factors > Post-Surgical Preservation

"There's no time limit on grief:" Women's perspectives on a novel reproductive grief screening tool

Bute JJ et al., 2023 Open Access PEC Innovation

Objective: Women who have experienced reproductive loss (i.e., miscarriage, stillbirth, abortion) evaluated the usefulness of a novel screening tool, Reproductive Grief Screen (RGS), to identify patie...

Pregnancy > Loss > Grief Assessment ToolsEthics/Philosophy > Patient Experience > Reproductive GriefResearch Methodology > Qualitative Research > Tool Development

Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort

Evanchuk JL et al., 2023 Open Access The Journal of Nutrition

Background: The maternal status of multiple micronutrients during pregnancy and postpartum and their potential associations with maternal health outcomes are largely undescribed. Objectives: This stu...

Pregnancy > Maternal Nutrition > Iron and Vitamin D StatusPregnancy > Maternal Mental Health > Antenatal DepressionDiagnostics > Biomarkers > Micronutrient Assessment in Pregnancy

Vaginal micronised progesterone for the prevention of hypertensive disorders of pregnancy: A systematic review and meta-analysis

Melo P et al., 2023 Open Access BJOG : an International Journal of Obstetrics and Gynaecology

Background: Treatment with vaginal progesterone reduces the risk of miscarriage and preterm birth in selected high-risk women. The hypothesis that vaginal progesterone can reduce the risk of hypertens...

Pregnancy > Complications > Hypertensive DisordersPregnancy > Treatment > Progesterone SupplementationResearch Methodology > Systematic Review and Meta-Analysis

State of the Fertility Sector 2022/2023

Human Fertilisation and Embryology Authority, 2023

# State of the fertility sector 2022/23 Annual publication on HFEA licensed centres (1st April 2022 – 31st March 2023) Published: 12th September 2023 [Download the underlying dataset as .xlsx](https:/...

General OB/GYN > Fertility Services > Regulatory OversightInfertility > Assisted Reproduction > IVF Clinic RegulationEthics/Philosophy > Policy > Fertility Treatment Regulation

Intraovarian Platelet-rich Plasma Administration Induced Spontaneous Ovulation in an Anovulatory Woman With PCOS

Wang R et al., 2023 Open Access JCEM Case Reports

The use of platelet-rich plasma (PRP) has become popular as an adjunct to fertility treatment for women with infertility, particularly those with low ovarian reserve and premature ovarian insufficienc...

PCOS > Treatment > Platelet-Rich PlasmaInfertility > Ovarian Factors > PRP Ovarian RejuvenationReproductive Endocrinology > Ovulation Induction > Novel Approaches

Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

Lahimer M et al., 2023 Open Access Frontiers in Public Health

The deleterious effects of chemical or non-chemical endocrine disruptors (EDs) on male fertility potential is well documented but still not fully elucidated. For example, the detection of industrial c...

Andrology > Environmental Factors > Endocrine DisruptorsAndrology > Semen Analysis > Chemical Exposure EffectsReproductive Endocrinology > Endocrine Disruptors > Male Effects

Repair of Isthmocele Following Embolization of Uterine Arteriovenous Malformation

Huang D et al., 2023 Journal of Minimally Invasive Gynecology

Objective: To present a case of concurrent uterine arteriovenous malformation (AVM) and isthmocele, treated with ethylene vinyl alcohol copolymer (EVAC) embolization of the AVM followed by robotic ist...

Surgery > Minimally Invasive > Robotic Isthmocele RepairSurgery > Vascular > Uterine AVM EmbolizationInfertility > Surgical Treatment > Cesarean Scar Defect Repair

Molar Pregnancy with Co-Existing Viable Fetus Delivered Preterm at 24 Weeks Gestation: A Case Report

Hassan H et al., 2023 Open Access International Medical Case Reports Journal

Maternal b-HCG levels fell to undetectable levels one month after birth without treatment. She was doing well and a follow-up six months later revealed no evidence of retained tissue or recurrence.

Pregnancy > Complications > Molar PregnancyPregnancy > Complications > Preterm BirthGeneral OB/GYN > Case Reports > Gestational Trophoblastic Disease

Fetoscopic laser photocoagulation for complex heterokaryotypic monochorionic twin management

Munoz JL et al., 2023 Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology

Data sharing not applicable - no new data generated

Pregnancy > Fetal Intervention > Fetoscopic Laser SurgeryPregnancy > Complications > Monochorionic Twin PregnancySurgery > Fetal Surgery > Placental Laser Photocoagulation

Case Reports from Women Using a Quantitative Hormone Monitor to Track the Perimenopause Transition

Meyers M et al., 2023 Open Access Medicina (Kaunas, Lithuania)

The fertility tracking of menstrual cycles during perimenopause with a quantitative hormone monitor is a novel undertaking. Women in regular menstrual cycles have been tracking their fertility using d...

Perimenopause/Menopause > Monitoring > Hormone TrackingFertility Awareness > Biomarkers > Urinary Hormone MonitoringRRM Methods > Special Populations > Perimenopause

Placental histology for targeted risk assessment of recurrent spontaneous preterm birth

Suresh S et al., 2023 American Journal of Obstetrics and Gynecology

Background: Spontaneous preterm birth significantly increases the risk for a recurrent preterm birth. Only a few identifiable clinical risk factors can be referenced in counseling for recurrent preter...

Pregnancy > Complications > Recurrent Preterm BirthDiagnostics > Histopathology > Placental PathologyPregnancy > Treatment > Progesterone Supplementation for Preterm Birth

Impact of thyroid autoantibodies and serum TSH level on clinical IVF outcomes

Moon KY et al., 2023 Open Access Taiwanese Journal of Obstetrics & Gynecology

Objective: This study aimed to investigate the impact of thyroid autoantibodies and serum TSH levels on clinical IVF outcomes. Materials and Methods: This study included 260 Korean women scheduled fo...

Reproductive Endocrinology > Thyroid Disorders > Thyroid Autoimmunity and IVFInfertility > Assisted Reproduction > IVF Outcomes and Thyroid FunctionDiagnostics > Hormonal Testing > TSH Thresholds in Fertility

Lack of evidence that progesterone in ovulatory cycles causes breast cancer

Gompel A et al., 2023 Climacteric : the Journal of the International Menopause Society

A recent Perspective article asserted that progesterone secretion during ovulatory cycles is the cause of breast cancer. However, we challenge most of the evidence developed in this publication. First...

Reproductive Endocrinology > Progesterone > Breast Cancer RiskMenstrual Cycle > Ovulatory Disturbances > Cancer Risk AssessmentEthics/Philosophy > Scientific Debate > Progesterone Safety Evidence

First trimester anatomy ultrasound for patients with obesity: a randomized controlled trial

Buskmiller C et al., 2023 American Journal of Obstetrics & Gynecology MFM

Background: Second-trimester ultrasound is the standard technique for fetal anatomy evaluation in the United States despite international guidelines and literature that suggest that first-trimester ti...

Pregnancy > Prenatal Imaging > First Trimester Anatomy UltrasoundDiagnostics > Ultrasound > Fetal Anatomy Assessment in ObesityResearch Methodology > Randomized Controlled Trial > Prenatal Imaging

Examining the co-occurrence of endometriosis and polycystic ovarian syndrome

Schliep KC et al., 2023 Open Access AJOG Global Reports

Background: Polycystic ovarian syndrome and endometriosis are 2 of the most common reproductive disorders among women but are thought to be unrelated. Objective: This study aimed to examine the overl...

Endometriosis > Comorbidities > PCOS Co-OccurrencePCOS > Comorbidities > Endometriosis OverlapDiagnostics > Differential Diagnosis > Endometriosis vs PCOS

3-Tier Endometriosis Symptom Self-Assessment Tool

Whittaker N. 3-Tier Endometriosis Symptom Self-Assessment Tool. RRM Academy. 2023.

An evidence-based, 3-tier endometriosis self-assessment developed by Dr. Naomi Whittaker, board-certified OB/GYN (MIGS, NFPMC, FCI). Evaluates 36 symptoms across three tiers of clinical suspicion -- V...

Endometriosis > Screening > Self-AssessmentPatient Education > Clinical Tools

Completion of Fetal Anatomy Evaluations in Women With Body Mass Index ≥ 50 kg/m(2)

Buskmiller C et al., 2023 Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

Objectives: As maternal body mass index (BMI) increases, fetal anatomy ultrasound becomes more challenging, less sensitive, and less likely to be complete. We sought to report our experience of incomp...

General OB/GYN > Prenatal Imaging > Fetal Anatomy UltrasoundPregnancy > Maternal Obesity > Ultrasound ChallengesDiagnostics > Prenatal Screening > Ultrasound Completion Rates

Long-Term Change in Bone Mineral Density in Women Living With HIV: A 10-Year Prospective Controlled Cohort Study

Heather M Macdonald et al., 2023 Open Access JBMR Plus

Women living with HIV (WLWH) may be at higher risk for osteoporosis and fragility fractures. However, limited prospective data describe long-term trajectories of bone mineral density (BMD) in WLWH ver...

Bone Health > HIV-Related > Women's Long-Term OutcomesGeneral OB/GYN > Infectious Disease > HIV and Bone HealthPerimenopause/Menopause > Bone Health > HIV Comorbidity

Former long-term use of combined hormonal contraception and glucose metabolism disorders in perimenopausal women: A prospective, population-based cohort study

Mosorin ME et al., 2023 Open Access Acta Obstetricia Et Gynecologica Scandinavica

Introduction: Current use of combined hormonal contraceptives worsens glucose tolerance and increases the risk of type 2 diabetes mellitus at late fertile age, but the impact of their former use on th...

Contraception/Comparison > Long-Term Effects > Metabolic OutcomesPerimenopause/Menopause > Metabolic Health > Prior ContraceptionReproductive Endocrinology > Glucose Metabolism > Hormonal Exposure

Exploring the lived experiences of debilitating period pain management in the UK

Vafapour P et al., 2023 British Journal of Pain

Background: Five to ten percent of women experience period pains that disrupt their lives yet 4 in 5 women believe that their claims for their dysmenorrhea are not taken seriously. Within the process ...

Menstrual Cycle > Symptoms > Dysmenorrhea ManagementGeneral OB/GYN > Patient Experience > Pain ManagementResearch Methodology > Qualitative Research > Lived Experience

Don't ignore perimenopause

Prior JC et al., 2023 Open Access CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

We agree with Lega and colleagues[1][1] that menopausal hormone therapy (MHT) has been shown in randomized controlled trials (RCTs) to be effective and safe for treating problematic vasomotor symptoms...

Perimenopause/MenopauseReproductive Endocrinology

Women's health, hormonal balance, and personal autonomy

Segarra I et al., 2023 Open Access Frontiers in Medicine

Hormone-based contraception disrupts hormonal balance, creating artificial states of anovulation and threatening women's health. We reviewed its main adverse effects and mechanisms on accelerated ovar...

Contraception/ComparisonReproductive Endocrinology