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Commentary On Infertility and Restorative Reproductive Medicine
In 1972, a seminal article was published demonstrating that women, adequately trained, could detect the approach of ovulation in the fertile window of their menstrual cycle. It was demonstrated that t...
Children’s executive functioning and health behaviors across pediatric life stages and ecological contexts
Optimizing Air Quality Monitoring: Comparative Analysis of Linear Regression and Machine Learning in Low-Cost Sensor Calibration
Background Low-cost sensors (LCS) are widely used for air quality monitoring, but their accuracy depends on proper calibration. This study compares linear regression (LR) and machine learning (ML) tec...
Association of Polycystic Ovary Syndrome With Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
OBJECTIVE: Despite certain studies indicating hearing impairments in individuals with polycystic ovary syndrome (PCOS), the correlation between PCOS and sensorineural hearing loss (SNHL) remains incon...
Identification of an aryl hydrocarbon receptor agonistic disperse dye in commercially available textile products by effect-directed analysis
Textile products contain various chemicals, making safety evaluation complex. We conducted an exploratory investigation of aryl hydrocarbon receptor (AhR) agonists in textile products using effect-dir...
Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions
Background: Measuring quantitative menstrual cycle hormones at home may help women better understand their postpartum and perimenopause fertility transitions, but these quantitative fertility monitors...
Ectopic Pregnancy
Ectopic pregnancy occurs when a fertilized egg implants outside the uterine cavity, a condition that affects approximately 1% to 2% of pregnancies in the United States. Ectopic pregnancy is a potentia...
Efficacy of open-label placebos for premenstrual syndrome: a randomised controlled trial
Objective: To investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS). Design: Randomised controlled trial. Setting: Switzerland, 2018-2020. Participants: 150 ...
2025 Canadian guideline for physical activity, sedentary behaviour and sleep throughout the first year post partum
This consensus aims to provide guidance for postpartum women and people, healthcare providers and exercise professionals on physical activity, sedentary behaviour and sleep throughout the first year p...
Higher Pregnancy Success Rates in Patients with Diminished Ovarian Reserve < 40 Years When Initially Treated by Intrauterine Insemination with Mild Ovarian Stimulation Compared to In Vitro Fertilization Alone: A Pilot Study
Four possible metabolic approaches to improving cardiac function in the presence of myocardial hypoxia have been considered. 1. It appears that there is increasing evidence which suggests that free fa...
The association of prenatal dietary factors with child autism diagnosis and autism-related traits using a mixtures approach: Results from the ECHO Cohort
Background: Previous research on the role of maternal diet in relation to autism has focused on examining individual nutrient associations. Few studies have examined associations with multiple nutrien...
Auditing Algorithmic Medical Systems to Uncover AI Harms and Remedy Racial Injustice
Abstract P1174: Endometriosis diagnosis, staging, and typology in relation to inflammatory cytokines
Introduction: Endometriosis, affecting 11% of reproductive-aged persons, is characterized by ectopic endometrial tissue and chronic inflammation. Prior research suggests those with endometriosis have ...
Abstract P1175: Endometriosis diagnosis, staging, and typology in relation to dyslipidemia
Background: Individuals with endometriosis, a gynecologic condition affecting approximately 11% of people with a uterus, may have an elevated risk for developing cardiovascular disease (CVD) later in ...
Progesterone supplementation after postovulatory mifepristone reduce changes in human endometrial gene expression
IN BRIEF: Progesterone supplementation reverses 83% of transcript changes in the secretory endometrium induced by postovulatory mifepristone, potentially mitigating its antiprogestogenic effects. ABST...
Appetite and Energy Intake in Laboratory and Free-Living Conditions Remain Consistent Across Menstrual Cycle Phases when Using Precise Measurement Methods
Self-reported dietary intake varies across menstrual cycle phases, but objective assessments of dietary intake together with appetite and resting metabolic rate (RMR) are limited. This study aimed to ...
Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?
Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we e...
Estrogen-Gut-Brain Axis: Examining the Role of Combined Oral Contraceptives on Mental Health Through Their Impact on the Gut Microbiome
Combined oral contraceptives (COCs) possess the ability to alter the normal composition of the gut microbiome and the permeability of the gastrointestinal (GI) tract, which may cause both gut-related ...
Hormonal birth control is associated with altered gut microbiota β-diversity in physically active females across the menstrual cycle: a pilot trial
Understanding changes to gut microbiota composition in response to hormonal birth control (HBC) may provide insight into the microbial mechanisms underlying the metabolic effects of HBC, for example, ...
Stroke and myocardial infarction with contemporary hormonal contraception: real-world, nationwide, prospective cohort study
Objective: To evaluate the association between contemporary hormonal contraceptive use and the risk of incident ischaemic stroke and myocardial infarction. Design: Real-world, nationwide, prospective ...
Welcome to the Journal of Restorative Reproductive Medicine
Welcome to the Journal of Restorative Reproductive Medicine, the official journal of the International Institute for Restorative Reproductive Medicine! JRRM is a peer-reviewed, open-access medical jou...
Hypertensive Blood Pressure in Adolescent Females With Polycystic Ovary Syndrome
INTRODUCTION: Polycystic ovary syndrome is associated with hypertension in women, but few population studies have examined findings among adolescents. This retrospective study examines PCOS and hypert...
Electronic health records-integrated mobile health interventions in primary care to improve hypertension management in Black/African American populations: a systematic review
Black/African American individuals face twice the risk of hypertension compared to non-Hispanic Whites in the United States (US). A synergistic strategy integrating primary care with Electronic Health...
Is endometriosis typology a potentially better classification system for assessing risk of female infertility?
Objective: To determine whether endometriosis typology, namely ovarian endometriomas (OE), deep infiltrating endometriosis (DIE), or superficial endometriosis (SE), correlates with fertility history. ...
Network meta-analysis on the efficacy of different interventions for treating thin endometrium
'I don't know what normal has been': a grounded theory exploration of the journey to endometriosis diagnosis
Hormonal imbalance in umbilical vein cord blood of pregnant women with endometriosis: a propensity score-matched analysis
National Patient Survey 2024
# National Patient Survey 2024 Survey of UK fertility patients: 2 September - 9 October 2024 Published: March 2025 [Download the underlying dataset as .xlsx](https://www.hfea.gov.uk/media/vf5bxixp/nat...
Endometriosis Quality of Life Cohort Study: Long-term Impact of Radical Laparoscopic Excision of Endometriosis
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associate...
Outcomes of in vitro fertilization cycles with embryo donation compared with double gamete donation with cryopreserved donor oocytes
OBJECTIVE: To evaluate the outcomes of embryo donation compared with those of double gamete donation with cryopreserved donor oocytes. DESIGN: Retrospective cohort study. SUBJECTS: The 2016-2019 Soc...
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global...
Laparoscopic-assisted ovariohysterectomy for pyometra with concurrent endometriosis in a captive cheetah (Acinonyx jubatus): A case report
BACKGROUND: Reproductive tract disorders are increasingly recognized in aging captive cheetahs (Acinonyx jubatus), a species listed as vulnerable by the International Union for Conservation of Nature....
Collision tumor of endometrial hepatoid adenocarcinoma and endometrial stromal sarcoma: a rare case and literature review
BACKGROUND: Endometrial hepatoid adenocarcinoma (HAC) is an exceedingly rare tumor. Histologically, the tumor is predominantly characterized by HAC with additional components, as documented in previou...
Research advances and future directions in female ADHD: the lifelong interplay of hormonal fluctuations with mood, cognition, and disease
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) in girls and women is under-recognised and under-researched, despite increasing awareness of clinical challenges and unmet needs. This rev...
Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes
Influential guidelines have supported the role of metformin in the management of polycystic ovary syndrome (PCOS) for a number of years. However, regulatory approvals for this therapeutic indication a...
Why women refuse Postpartum IUCD?
BACKGROUND: Women are highly motivated and receptive to accepting family planning methods during the antenatal period. Hence, we conducted this study to evaluate the refusal rate and reasons for the r...
Sexually antagonistic selection, X-chromosome relatedness and the evolution of menopause in killer whales
The human menopause is hypothesized to be an adaptive trait that allows post-reproductive females to invest in, and avoid reproductive conflict with, their existing offspring and grand-offspring, ther...
Uterine artery S/D ratio and serum CA125 as predictors of early pregnancy loss in women with ovarian endometriomas: a retrospective case-control study
BACKGROUND: Endometriosis affects approximately 10% of women of reproductive age and is associated with increased risks of infertility and miscarriage. Although the spontaneous miscarriage rate in wom...
Core facets of divine forgiveness: a study across monotheistic religions
INTRODUCTION: Among the religious factors that significantly contribute to believers' well-being, research on the personal experience of divine forgiveness (DF) remains in its infancy. The aim of this...
Is endometrial thickness associated with fertility outcomes in intrauterine insemination? a cohort study
BACKGROUND: Intrauterine insemination (IUI) is the first line treatment for conditions such as unexplained or mild male factor infertility. Endometrial thickness (EMT) is an important indicator for pr...
Investigating the effects of melatonin on structural and vascular changes in an experimentally induced ovarian hyperstimulation syndrome model : Effects of melatonin on experimentally induced ovarian hyperstimulation syndrome
Ovarian hyperstimulation syndrome (OHSS) is a serious complication commonly encountered in patients with infertility undergoing ovulation induction therapy. This study investigates histomorphological ...
Nurses' perspectives on injection devices for controlled ovarian stimulation in in-vitro fertilisation: a cross-sectional survey from the GCC countries
INTRODUCTION: The design and functionality of injection devices for controlled ovarian stimulation (COS) significantly influence dose accuracy and patient comfort, affecting adherence and treatment su...
Progestin-primed ovarian stimulation protocol in patients undergoing assisted reproductive technology
PURPOSE: To evaluate the effectiveness and safety of the novel protocol-progestin-primed ovarian stimulation (PPOS) protocol during controlled ovarian hyperstimulation (COH), in patients undergoing in...
Ongoing pregnancy rate is associated with trigger-day progesterone level in letrozole/clomiphene intrauterine insemination cycles
PURPOSE: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A...
Efficacy & safety of sodium-glucose cotransporter-2 inhibitors in polycystic ovary syndrome: A meta-analysis with trial sequential analysis
Background & objectives Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterised by menstrual irregularities, hirsutism, acne, obesity, infertility, and other features adversely affec...
Live birth rates are unrelated to sex-steroid levels on ET day in a dydrogesterone-based 'programmed-ovulatory FET' protocol: a multi-centric prospective cohort study
STUDY QUESTION: What are the effects of three-times-a-day 10 mg oral dydrogesterone (DYD), initiated in the late follicular phase of natural menstrual cycles to induce endometrial receptivity for froz...
Human Decidual RUNX1 Promotes Angiogenesis and Trophoblast Differentiation by Regulating Extracellular Vesicle Signaling
During early pregnancy, human endometrial stromal cells differentiate into secretory decidual cells via a process regulated by ovarian steroid hormones. Decidual cells play a crucial role by secreting...
Hormonal contraception, past, present, and future part 2: optimizing combined oral contraceptives to decrease risks for healthy women
INTRODUCTION: Pincus and his group's initial research on hormonal contraception focused on progesterone. However, the natural compound could not be utilized in clinical practice because of the high in...