Department of Gynaecological Endocrinology and Fertility Disorders, University of Heidelberg, Vossstrasse 9, 69115 Heidelberg, Germany. petra.frank-herrmann@med.uni-heidelberg.deROR
PMID 41475700 41475700 DOI 10.1016/j.fertnstert.2025.10.021 10.1016/j.fertnstert.2025.10.021
Cite this article
Frank-Herrmann, P., Freundl-Schütt, T., & Gnoth, C. (2026). Response to “The illusion of reproductive choice: how restorative reproductive medicine violates reproductive autonomy and informed consent”. Fertility and sterility, 125(1), 179. https://doi.org/10.1016/j.fertnstert.2025.10.021
Frank-Herrmann P, Freundl-Schütt T, Gnoth C. Response to “The illusion of reproductive choice: how restorative reproductive medicine violates reproductive autonomy and informed consent”. Fertility and Sterility. 2026;125(1):179. doi:10.1016/j.fertnstert.2025.10.021
Frank-Herrmann, P., et al. "Response to “The illusion of reproductive choice: how restorative reproductive medicine violates reproductive autonomy and informed consent”." Fertility and sterility, vol. 125, no. 1, 2026, pp. 179.
Peipert et al. (1) claim that restorative reproductive medicine (RRM) originated as a political and religious movement with the purpose to limit access to in vitro fertilization (IVF). In so doing, they mischaracterize the origin, development, and aims of RRM, as articulated by the International Institute for Restorative Reproductive Medicine, founded in 2000. They do not refer to any peer-reviewed medical literature published by clinicians and researchers working to develop RRM. Objecting that certain political or economic interests promote RRM (or, alternatively, IVF) does not constitute the basis for an evidence-based scientific critique or discussion. Thus, their editorial falls short of a serious effort to understand RRM scientifically.
Practice Committee of the American Society for Reproductive Medicine and Practice Committee of the Society for Reproductive Endocrinology and Infertility, 2026·Fertility and sterility
Luteal phase deficiency (LPD) is a clinical diagnosis associated with abnormal luteal phase length of ≤10 days. Potential etiologies of LPD include inadequate progesterone duration, inadequate progesterone levels, or endometrial progesterone resistance. Luteal phase deficiency has been described in association with medical conditions, but also in fertile, normally menstruating women. Although progesterone is important for the process of implantation and early embryonic development, LPD has not been proven to be an independent entity causing infertility or recurrent pregnancy loss. Controversy exists regarding the multiple proposed measures for diagnosing LPD, and assuming it can be diagnosed accurately, whether treatment improves outcomes. This document replaces the document of the same name, last published in 2021 (Fertil Steril 2021;115(6):1416-23).
Practice Committee of the American Society for Reproductive Medicine, 2026·Fertility and Sterility
Current strategies for the assessment and treatment of recurrent pregnancy loss are discussed. This replaces the previous document, titled, "Evaluation and treatment a committee opinion," last published in 2012.
This narrative review examines the evidence for medical optimization of inflammatory conditions, vitamin deficiencies, endocrine disorders, immune dysregulation, oligo-ovulation, and luteal phase factors to improve fertility outcomes in women attempting to conceive through natural or timed intercourse. Overall, there is a paucity of data with respect to these categories among patients pursuing timed intercourse, precluding our ability to draw strong recommendations. However, there is strong evidence supporting treatment of endocrine disorders, specifically overt thyroid dysfunction and hyperprolactinemia, as well as oligo-ovulation. Conversely, treatment of subclinical hypothyroidism is not recommended. The current data are insufficient to support empiric use of antiinflammatory medications, corticosteroids, thyroid hormones, or vitamins or supplements to improve chances of pregnancy in a general infertility population.