Reproductive Surgery · Adhesion Prevention

Prevention of postoperative tubal adhesions. Comparative study of commonly used agents

Hodger GD, diZerega GS

Published January 15, 1980 American Journal of Obstetrics and Gynecology, 136(2), 173-178
DOI 10.1016/0002-9378(80)90591-8 PMID 6766273

Abstract

Tubal abrasions were surgically induced in 25 rhesus monkeys following demonstration of tubal patency. Five monkeys received dexamethasone, promethazine, and ampicillin perioperatively, five received intraperitoneal 10% dextran 40, five received intraperitoneal 32% dextran 70, and 10 received no additional therapy. Fimbrial biopsies were obtained from two additional monkeys treated with 32% dextran 70 before and postoperatively on days 2, 5, and 7. Only those treated with 32% dextran 70 retained tubal patency and avoided development of adhesions, involving fimbria, omentum, ovary, uterus, and bladder. Histologic examination of fimbrial biopsies demonstrated sufficient epithelial repair to have occurred during the 5 days 32% dextran 70 remained in the pelvin cavity to prevent adhesion formation.

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Reproductive Surgery › Adhesion Prevention › Barrier Agents · Infertility › Tubal Factor › Distal Tubal Disease
PMID 6766273 6766273 DOI 10.1016/0002-9378(80)90591-8 10.1016/0002-9378(80)90591-8 Hodger et al. 1980, Hodger 1980