Abstract
Objective To compare the effect of fertility drugs and IVF on the outcome of triplet pregnancies.
Design Prospective clinical study.
Setting A single university medical center.
Patients One hundred six consecutive triplet pregnancies treated from 1984 through 1992.
Main Outcome Measures The frequency of pregnancy loss, livebirths, and antenatal and neonatal complications was compared in spontaneous, clomiphene citrate (CC), menotropins, and IVF triplet pregnancies.
Results Eighty-one of the 106 (76.4%) triplet pregnancies progressed beyond 25 weeks, comprising 6 of 7 (85.7%) spontaneous pregnancies, 13 of 16 (81.2%) CC induced, 44 of 56 (78.6%) menotropin induced, and 18 of 27 (66.6%) IVF gestations. There were no significant differences in the stillbirth and neonatal mortality rates according to the mode of conception. The mean gestational ages and the mean birth weights were similar in the four groups. The frequency of premature contractions, premature rupture of membranes, cesarean section, and neonatal complications were similar in the ovulation induction and IVF pregnancies.
Conclusion Triplet pregnancies after ovulation induction and IVF have a similar outcome.
triplet pregnancy outcomes fertility drugs vs IVF, ovulation induction triplet pregnancy complications, clomiphene citrate menotropins IVF triplet outcomes, multiple gestation fertility treatment neonatal outcomes, triplet pregnancy preterm birth neonatal mortality, IVF triplet pregnancy stillbirth neonatal complications, ovulation induction multiple pregnancy gestational age, triplet pregnancy cesarean section premature rupture membranes, fertility treatment higher order multiples prospective study, Lipitz triplet pregnancy fertility drug outcomes
PMID 8243681 8243681 DOI 10.1016/s0015-0282(16)56405-x 10.1016/s0015-0282(16)56405-x
Keywords
Adult, Birth Weight, Clomiphene/therapeutic Use, Embryo Transfer, Female, Fertilization in Vitro, Fetal Death, Gestational Age, Humans, Menotropins/therapeutic Use, Ovulation Induction, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prospective Studies, Triplets, Clomiphene, Menotropins